Hotta Yugi, Yoshioka Naoki, Sakamoto Asami, Inagaki Masayasu, Ito Ryota, Shiraki Kenta, Kiriyama Ayami, Yokoyama Toshihiko, Fujino Masahiko, Doisaki Masao
Department of Gastroenterology and Hepatology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.
Department of Respiratory Medicine, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.
Clin J Gastroenterol. 2025 Apr;18(2):337-342. doi: 10.1007/s12328-024-02086-8. Epub 2024 Dec 28.
Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer rarely leads to disseminated BCG infections, most of which occur early after BCG instillations or in immunocompromised patients. We report late-onset disseminated BCG infection after intravesical BCG immunotherapy in a non-immunocompromised patient. A 78-year-old non-immunocompromised man was admitted with fever and hepatosplenomegaly. He had received intravesical BCG immunotherapy four years earlier. Granulomas were detected in multiple organs and BCG was identified in urine and bone marrow fluid, leading to a diagnosis of disseminated BCG infection. Longitudinal measurements of liver and spleen volumes by computed tomography were useful in determining treatment efficacy.
膀胱内注射卡介苗（BCG）免疫疗法治疗膀胱癌很少导致播散性卡介苗感染，其中大多数发生在卡介苗灌注后早期或免疫功能低下的患者中。我们报告了一例非免疫功能低下患者在膀胱内注射卡介苗免疫治疗后发生的迟发性播散性卡介苗感染。一名78岁非免疫功能低下男性因发热和肝脾肿大入院。他四年前接受过膀胱内卡介苗免疫治疗。在多个器官中检测到肉芽肿，尿液和骨髓液中发现了卡介苗，从而诊断为播散性卡介苗感染。通过计算机断层扫描对肝脏和脾脏体积进行纵向测量有助于确定治疗效果。
