Kopf A W, Levine L J, Rigel D S, Friedman R J, Levenstein M
J Dermatol Surg Oncol. 1985 Mar;11(3):275-80. doi: 10.1111/j.1524-4725.1985.tb03005.x.
The prevalence of congenital-nevus-like nevi (CNLN) in a group of 105 adults who had malignant melanoma (MM) was compared with that in a control group of 601 adults not afflicted by MM. Total cutaneous examinations were performed on both groups. The control group presented with complaints other than pigmented lesions. In this series, 10 (9.5%) of the group with MM had clinically diagnosed CNLN 1.5 cm or larger in diameter. These CNLN were not in contiguity with the MM sites. The 9.5% prevalence of CNLN in the group with MM was significantly higher (p less than 0.005) than the 2.5% CNLN observed in the control population. None of the patients in either group had large congenital nevocytic nevi (greater than or equal to 20 cm). In addition, in the group with MM, 5 patients (4.8%) had nevi spili (NS) and 13 (12.4%) had café-au-lait spots (CLS). The prevalence rates for these two types of pigmented lesions were not significantly different from those observed in the nonmelanoma control group (2.3% for NS; 13.8% for CLS). The relative risk for developing MM is 4.1 in people with CNLN compared with those without CNLN, which indicates that these nevi may be markers for individuals prone to develop malignant melanoma.
在105名患有恶性黑色素瘤（MM）的成年人群体中，先天性痣样痣（CNLN）的患病率与601名未患MM的成年对照组人群进行了比较。对两组人群均进行了全面的皮肤检查。对照组有色素沉着病变以外的主诉。在该系列研究中，患有MM的人群中有10人（9.5%）临床诊断为直径1.5厘米或更大的CNLN。这些CNLN与MM部位不相邻。MM组中CNLN的患病率为9.5%，显著高于对照组中观察到的2.5%的CNLN患病率（p小于0.005）。两组患者均无大型先天性痣细胞痣（大于或等于20厘米）。此外，在患有MM的人群中，5名患者（4.8%）有雀斑样痣（NS），13名患者（12.4%）有咖啡斑（CLS）。这两种色素沉着病变的患病率与非黑色素瘤对照组中观察到的患病率无显著差异（NS为2.3%；CLS为13.8%）。与没有CNLN的人相比，有CNLN的人患MM的相对风险为4.1，这表明这些痣可能是易患恶性黑色素瘤个体的标志物。
