Morsy Hadeer M, Zaky Mohamed Y, Yassin Nour Y S, Khalifa Ashraf Y Z
Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O.Box 62521, Beni-Suef, Egypt.
Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O.Box 62521, Beni-Suef, Egypt.
Int J Pharm. 2025 Feb 10;670:125135. doi: 10.1016/j.ijpharm.2024.125135. Epub 2024 Dec 26.
Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.
黄酮类化合物是一类天然多酚分子，由于其广泛存在的特性和多样的生物活性，包括抗氧化、抗炎和抗癌作用，已引起了大量的研究关注，这使得它们在各个科学领域都颇具吸引力。在这方面，使用黄酮类纳米颗粒递送系统是为了克服生物利用度低、生物活性差、水溶性不佳、全身吸收以及代谢旺盛等问题。因此，本综述总结了纳米颗粒（脂质体、聚合物和固体脂质纳米颗粒）的分类以及使用纳米颗粒 - 黄酮类制剂提高黄酮类生物利用度的优势。此外，本综述阐述了基于纳米颗粒的黄酮类疗法的开创性生物医学应用，以及使用黄酮类纳米颗粒递送系统时的安全性和毒性考量。
