Dhankhar Sanchit, Kumar Jatin, Chauhan Samrat, Zahoor Ishrat, Wani Shahid Nazir, Saini Monika, Borsha Jamila Akter, Yasmin Sabina, Ansari Mohammad Yousuf
Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Chitkara University School of Pharmacy, Chitkara University, Solan, Himachal Pradesh, India.
Inflammopharmacology. 2025 Mar 29. doi: 10.1007/s10787-025-01722-0.
Arthritis is an autoimmune disorder that predominantly causes inflammation and impacts peripheral joints. Even though immunosuppressive and NSAIDs or non-steroidal anti-inflammatory medicines are implemented for the management of this disorder, sbut they carry some severe side effects along with them. Therefore, society requires treatment with fewer side effects and powerful anti-arthritic properties, such as flavonoids. These are the most prevalent phenolic compounds found in nature that have potent antioxidant, and immunomodulatory activity and there are several bioactive flavonoids that carry potent anti-inflammatory properties. Nevertheless, only a handful has reached their clinical use. Still, in both clinical and preclinical models of arthritis, flavonoids found in the diet have been shown to reduce swelling in joints and arthritis symptoms. There are only a few scientific studies regarding their mechanisms of action in arthritis. However, the arthritic potential of dietary flavonoids is insufficient because of their limited solubility, absorption, and fast metabolism. Nanocarriers may enhance the bioavailability of flavonoids. This review examines the therapeutic effects of the most prevalent and abundant flavonoid groups on arthritis. Specifically, the modes of action of the most important flavonoids on the chemical messengers in the body that contribute to the signalling of joint inflammation-related indicators of arthritis are discussed in more detail.
关节炎是一种自身免疫性疾病，主要引发炎症并影响外周关节。尽管免疫抑制剂和非甾体抗炎药（NSAIDs）被用于治疗这种疾病，但它们也伴随着一些严重的副作用。因此，社会需要副作用更少且具有强大抗关节炎特性的治疗方法，比如黄酮类化合物。这些是自然界中最普遍存在的酚类化合物，具有强大的抗氧化和免疫调节活性，并且有几种生物活性黄酮类化合物具有强大的抗炎特性。然而，只有少数几种已进入临床应用。尽管如此，在关节炎的临床和临床前模型中，饮食中发现的黄酮类化合物已被证明可以减轻关节肿胀和关节炎症状。关于它们在关节炎中的作用机制只有少数科学研究。然而，由于其溶解性、吸收性有限以及代谢快，饮食中黄酮类化合物的抗关节炎潜力不足。纳米载体可能会提高黄酮类化合物的生物利用度。这篇综述探讨了最普遍且含量丰富的黄酮类化合物组对关节炎的治疗作用。具体而言，更详细地讨论了最重要的黄酮类化合物对体内化学信使的作用模式，这些化学信使有助于关节炎相关关节炎症指标的信号传导。
