Klg Afeeza, Priyadharshini Boopathy, Vasugi Suresh, Dilipan Elangovan
Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
Int J Biol Macromol. 2025 Mar;292:139171. doi: 10.1016/j.ijbiomac.2024.139171. Epub 2024 Dec 26.
Cancer remains a major global health concern due to several factors. These include the difficulty in accessing effective drugs, the high toxicity of available treatments, and the emergence of resistance to therapy. As a result, alternative strategies, such as the use of microbial enzymes, have gained attention as potential solutions to these challenges. Microbial enzymes have shown promise in inhibiting the uncontrolled growth of tumor cells through various mechanisms. In this comprehensive review, our objective is to emphasize the importance of pivotal microbial enzymes in fighting cancer and their ability to hinder the growth of tumors or cancer cells. The review article serves as a scientific roadmap for researchers, clinicians, and industry stakeholders exploring the therapeutic potential of biosynthetic enzymes in cancer treatment. It emphasizes the quest for effective and sustainable cancer therapies, presenting the possibility of personalized treatments with fewer side effects than traditional therapies.
由于多种因素,癌症仍然是全球主要的健康问题。这些因素包括难以获得有效的药物、现有治疗方法的高毒性以及对治疗产生的耐药性。因此,诸如使用微生物酶等替代策略作为应对这些挑战的潜在解决方案而受到关注。微生物酶已通过各种机制在抑制肿瘤细胞的无节制生长方面显示出前景。在这篇全面的综述中,我们的目标是强调关键微生物酶在抗癌中的重要性及其阻碍肿瘤或癌细胞生长的能力。这篇综述文章为研究人员、临床医生和行业利益相关者探索生物合成酶在癌症治疗中的治疗潜力提供了科学路线图。它强调了寻求有效且可持续的癌症治疗方法,展示了比传统疗法副作用更少的个性化治疗的可能性。