Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China.
Signal Transduct Target Ther. 2024 Jul 17;9(1):175. doi: 10.1038/s41392-024-01856-7.
Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive and remarkable transformation. Emerging as fervently pursued modalities are small molecule targeted agents, antibody-drug conjugates (ADCs), cell-based therapies, and gene therapy. These cutting-edge treatment modalities not only afford personalized and precise tumor targeting, but also provide patients with enhanced therapeutic comfort and the potential to impede disease progression. Nonetheless, it is acknowledged that these therapeutic strategies still harbour untapped potential for further advancement. Gaining a comprehensive understanding of the merits and limitations of these treatment modalities holds the promise of offering novel perspectives for clinical practice and foundational research endeavours. In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential solutions. The aim is to assist clinicians and researchers in gaining a deeper understanding of these diverse treatment options, enabling them to carry out effective treatment and advance their research more efficiently.
传统的治疗方法,如化疗和放疗,给癌症患者带来了沉重的身体和心理挑战。令人鼓舞的是,肿瘤治疗的格局已经发生了全面而显著的转变。小分子靶向药物、抗体药物偶联物(ADC)、细胞疗法和基因疗法等新兴治疗方法正受到热烈追捧。这些前沿治疗方法不仅提供了个性化和精确的肿瘤靶向治疗,还为患者提供了更好的治疗舒适度,并有可能阻止疾病进展。然而,我们也认识到这些治疗策略仍有进一步发展的潜力。全面了解这些治疗方法的优缺点有望为临床实践和基础研究提供新的视角。在这篇综述中,我们讨论了不同的治疗方法,包括小分子靶向药物、肽类药物、抗体药物、细胞治疗和基因治疗。我们将详细解释每种方法,包括其发展现状、临床挑战和潜在解决方案。目的是帮助临床医生和研究人员更深入地了解这些多样化的治疗选择,使他们能够进行有效的治疗,并更有效地推进他们的研究。