追溯往昔：分子复活技术助力发现古代β-防御素并突显其进化历程。
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history.
作者信息
Gosti Françoise
机构信息
IPSiM, CNRS, INRAE, Institut Agro, Univ. Montpellier, 2, Place P. Viala, F-34 060 Cedex 2 Montpellier, France.
出版信息
Trends Biochem Sci. 2025 Mar;50(3):173-174. doi: 10.1016/j.tibs.2024.12.002. Epub 2024 Dec 27.
PMID:39732526
Abstract
Molecular de-extinction is an innovative science aiming to discover, synthesize, and characterize molecules throughout evolution. Recent work by Ferreira et al. involved mining ancient genomes to search for antimicrobial defensins. They discovered six ancient β-defensins, revealing their evolutionary history and uncovering their structural and biochemical properties, which could feed medical applications.
摘要
分子复活是一门旨在发现、合成和表征整个进化过程中的分子的创新科学。费雷拉等人最近的工作涉及挖掘古代基因组以寻找抗菌防御素。他们发现了六种古代β-防御素，揭示了它们的进化历史，并揭示了它们的结构和生化特性，这可能为医学应用提供依据。
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