Liu Hezuo, Zhu Xiaohong, Ge Bin, Huang Minhui, Li Xing
Ninghai Maternal and Child Health Hospital, Ning Bo, Zhejiang, China.
Ninghai Second Hospital, Ning Bo, Zhejiang, China.
Rev Environ Health. 2024 Dec 30;40(2):437-444. doi: 10.1515/reveh-2024-0147. Print 2025 Jun 26.
The goal is to provide light on the contentious relationship between screen exposure and childhood autism spectrum disorder (ASD). By conducting two meta-analyses that showed a potential association, including screen exposure effect by ASD and ASD risk by screen exposure, we aimed to clarify the potential causality between screen exposure and childhood ASD.
The literature published up to December 2023 were systematically collected, and the combined effect values of weighted mean difference (WMD) and 95 % confidence interval (CI) and odds ratio (OR) and 95 % CI were calculated using two meta-analyses using the STATA 12.0. A total of 197,357 children, including 4,599 childhood ASD, were finally included in 10 studies. The results showed that children with ASD had higher levels of screen time exposure than healthy controls (combined effect value WMD=0.27, 95 % CI: 0.12-0.41, p<0.001). An increased risk of ASD was also found in children with high screen exposure compared to the low screen exposure group (OR=1.5395 % CI: 1.14-2.06).
The development of childhood ASD may be associated with screen exposure. Future prospective studies are needed to verify the relationship between screen exposure and ASD in children.
目的是阐明屏幕暴露与儿童自闭症谱系障碍(ASD)之间存在争议的关系。通过进行两项显示潜在关联的荟萃分析,包括ASD对屏幕暴露的影响以及屏幕暴露导致ASD的风险,我们旨在阐明屏幕暴露与儿童ASD之间的潜在因果关系。
系统收集了截至2023年12月发表的文献,并使用STATA 12.0通过两项荟萃分析计算了加权平均差(WMD)和95%置信区间(CI)以及比值比(OR)和95%CI的合并效应值。最终,10项研究共纳入了197357名儿童,其中包括4599名患有儿童ASD的儿童。结果显示,患有ASD的儿童的屏幕暴露时间水平高于健康对照组(合并效应值WMD = 0.27,95%CI:0.12 - 0.41,p < 0.001)。与低屏幕暴露组相比,高屏幕暴露儿童患ASD的风险也有所增加(OR = 1.53,95%CI:1.14 - 2.06)。
儿童ASD的发展可能与屏幕暴露有关。未来需要进行前瞻性研究以验证儿童屏幕暴露与ASD之间的关系。