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德国南部环境分离株的抗生素敏感性情况

Antibiotic susceptibility situation of environmental isolates in Southern Germany.

作者信息

Lang Hannah, Marschang Rachel E, Bismarck Doris, Heusinger Anton, Müller Elisabeth, Felten Martin

机构信息

Laboklin GmbH & Co KG, Steubenstraße 4, 97688 Bad Kissingen, Germany E-mail:

Laboklin GmbH & Co KG, Steubenstraße 4, 97688 Bad Kissingen, Germany.

出版信息

J Water Health. 2024 Dec;22(12):2414-2422. doi: 10.2166/wh.2024.490. Epub 2024 Nov 26.

Abstract

Antimicrobial resistance is an emerging problem in hospitals and long-term healthcare facilities. Early detection of susceptibility pattern changes in pathogenic bacteria can prevent treatment failures. Therefore, this study chose to investigate the antibiotic susceptibility situation of isolates from hospitals and long-term healthcare facilities in Southern Germany. Serogroups and minimal inhibitory concentrations (MICs) of nine antibiotics were determined from 41 strains. In total, 28% of the collected strains belonged to the more pathogenic serogroup 1, whereas 72% belonged to serogroups 2-14. Among the tested antibiotics, rifampicin had the lowest MIC value. The MIC values can be summarized in the following order: rifampicin < levofloxacin < moxifloxacin < ciprofloxacin < clarithromycin < azithromycin < erythromycin < doxycycline < tigecycline.

摘要

抗菌药物耐药性是医院和长期医疗保健机构中一个新出现的问题。早期发现病原菌药敏模式的变化可以预防治疗失败。因此,本研究选择调查德国南部医院和长期医疗保健机构分离株的抗生素敏感性情况。从41株菌株中测定了9种抗生素的血清群和最低抑菌浓度(MIC)。总共,28%的收集菌株属于致病性更强的血清群1,而72%属于血清群2 - 14。在所测试的抗生素中,利福平的MIC值最低。MIC值可按以下顺序总结:利福平<左氧氟沙星<莫西沙星<环丙沙星<克拉霉素<阿奇霉素<红霉素<多西环素<替加环素。

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