Nahayati Mohammad Ali, Habibi Dashtebayaz Ahmad, Taghipour Ali, Baghaei Mahdieh
Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Pediatric Resident, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mult Scler Relat Disord. 2025 Jan;93:106217. doi: 10.1016/j.msard.2024.106217. Epub 2024 Dec 8.
Multiple sclerosis (MS) is a major global health problem as a growing debilitating disease and according to the Global Burden of Diseases study in 2016 has had a 40 % prevalence increase in Iran during the 3 previous decades; far more from the Global prevalence which only increased about 10 %. Razavi Khorasan is the second most populous province in Iran with over 6.5 million people and its MS status is not clear; therefore, this study aims to define the current epidemiologic trend of MS in Razavi Khorasan METHODS AND MATERIALS: We performed this cross-sectional, analytical study in Khorasan Razavi Multiple sclerosis Center during 2021-2023. The data was extracted from the registry system for MS patients held in the center. The cases were all MS patients of the province numbered 4723. The sex- and age- standardized ratios were measured and the annual incidence and prevalence rates of MS were calculated using the province population information and so the epidemiologic trend of MS in the province was obtained.
Of over 4700 MS patients in the province in 2021, 78 % were female. More than 40 % had academic education. In 2021 most patients lived in their 4th (about 40 %) and 5th (about 28 %) decades of life. Most of the patients were aged 20-29 years (37 %) and 30-39 years (34 %) at the time of diagnosis and the average duration of disease was 7 years among all patients until 2021. The annual incidence in Khorasan Razavi rose gradually from 1.57 to 6.40 person-years during 2006-2020; with a steeper slope in females compared with males. The prevalence of MS in 2021 was about 71.7 per 100,000 population (112.7 for females and 31.3 for males), approximately 80 % more than the prevalence in 2006 relative to population growth.
There is an upward trend of multiple sclerosis in Razavi Khorasan; which is probably one of the fastest growth patterns in the region because it has been about two-fold as fast as in Tehran with the highest prevalence rates in Iran. Therefore, there should be extensive plans for managing the disease with secondary prevention in the coming years to decrease the complications and disabilities associated with disease progression.
多发性硬化症（MS）作为一种日益使人衰弱的疾病，是一个重大的全球健康问题。根据2016年全球疾病负担研究，伊朗在过去三十年中MS患病率增长了40%；远高于全球仅约10%的患病率增长。拉扎维霍拉桑是伊朗人口第二多的省份，有超过650万人，其MS状况尚不清楚；因此，本研究旨在确定拉扎维霍拉桑MS的当前流行病学趋势。
我们于2021 - 2023年在霍拉桑拉扎维多发性硬化症中心进行了这项横断面分析研究。数据从该中心保存的MS患者登记系统中提取。病例为该省所有4723名MS患者。测量了性别和年龄标准化比率，并使用该省人口信息计算了MS的年发病率和患病率，从而得出该省MS的流行病学趋势。
2021年该省4700多名MS患者中，78%为女性。超过40%拥有学术教育背景。2021年，大多数患者处于人生的第4个十年（约40%）和第5个十年（约28%）。大多数患者在诊断时年龄为20 - 29岁（37%）和30 - 39岁（34%），到2021年所有患者的疾病平均病程为7年。2006 - 2020年期间，拉扎维霍拉桑的年发病率从1.57逐渐上升至6.40/人年；女性的上升斜率比男性更陡。2021年MS的患病率约为每10万人71.7例（女性为112.7例，男性为31.3例），相对于人口增长，比2006年的患病率高出约80%。
拉扎维霍拉桑的多发性硬化症呈上升趋势；这可能是该地区增长最快的模式之一，因为其增长速度约为伊朗患病率最高的德黑兰的两倍。因此，未来几年应制定广泛的计划，通过二级预防来管理该疾病，以减少与疾病进展相关的并发症和残疾。
