Velasco Eric R, Nabás Jaime F, Torrents-Rodas David, Arias Bárbara, Torrubia Rafael, Fullana Miquel A, Andero Raül
Institut de Neurociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
Clinical Psychology and Psychotherapy, Institute of Psychology, Faculty of Psychology and Movement Sciences, Universität Hamburg, Germany.
Biol Psychol. 2025 Jan;194:108981. doi: 10.1016/j.biopsycho.2024.108981. Epub 2024 Dec 27.
Women are known to have twice as much lifetime prevalence of post-traumatic stress disorder (PTSD) as men do. It has been reported that the risk genotype (CC) of a single nucleotide polymorphism (SNP) (rs2267735) in the pituitary adenylate cyclase-activating polypeptide (PACAP-PAC1R) system is associated with PTSD risk and altered fear conditioning and fear extinction in women. Surprisingly, no previous work has studied the effect of this SNP on fear conditioning, extinction, or generalization in non-traumatized/low trauma load women. Here, two separate groups of women underwent either a two-day fear conditioning and fear extinction paradigm, or a one-day fear conditioning and fear generalization paradigm. Results showed no significant differences between genotypes in conditioned stimulus discrimination, during fear acquisition, extinction, or generalization. These findings suggest that the previously reported fear processing impairments in traumatized CC women are not a consequence of this genotype alone, but likely dependent on the interaction between this genetic risk and the exposure to traumatic stressors.
众所周知，女性创伤后应激障碍（PTSD）的终生患病率是男性的两倍。据报道，垂体腺苷酸环化酶激活多肽（PACAP-PAC1R）系统中一个单核苷酸多态性（SNP）（rs2267735）的风险基因型（CC）与PTSD风险相关，并且会改变女性的恐惧条件反射和恐惧消退。令人惊讶的是，之前没有研究探讨过该SNP对未受过创伤/创伤负荷低的女性的恐惧条件反射、消退或泛化的影响。在此，两组不同的女性分别接受了为期两天的恐惧条件反射和恐惧消退范式，或为期一天的恐惧条件反射和恐惧泛化范式。结果显示，在条件刺激辨别、恐惧习得、消退或泛化过程中，不同基因型之间没有显著差异。这些发现表明，之前报道的受过创伤的CC基因型女性的恐惧处理障碍并非仅由该基因型导致，而可能取决于这种遗传风险与创伤性应激源暴露之间的相互作用。
