Melconian A K, Fleurette J, Brun Y
J Hyg (Lond). 1985 Feb;94(1):23-9. doi: 10.1017/s002217240006109x.
Staphylococci from 22 cases of toxic shock syndrome with onsets between 1981 and March 1983 have been studied. Another four cases were detected by abstract surveillance. Three of these patients died. The case histories show that the syndrome occurs in women during menstruation as well as in males and in children, and is associated with Staphylococcus aureus infections. The production of enterotoxins (A, B, C) and toxic shock toxin by S. aureus isolates from toxic shock syndrome was investigated. Twenty-two of the 23 isolates were found to be toxigenic: 7 produced enterotoxin A, 8 produced enterotoxin B, 3 produced enterotoxin C and 13 produced toxic shock toxin. The latter was found with enterotoxin A in five cases, and with enterotoxins A and B in only one case. Sixty-three percent of 46 S. aureus strains isolated from the vagina of patients with diseases other than toxic shock syndrome produced toxin; eight of these strains produced toxic shock toxin.
对1981年至1983年3月期间发病的22例中毒性休克综合征患者的葡萄球菌进行了研究。通过摘要监测又发现了另外4例。其中3例患者死亡。病例记录显示，该综合征在女性月经期间以及男性和儿童中均有发生，且与金黄色葡萄球菌感染有关。对从中毒性休克综合征患者中分离出的金黄色葡萄球菌产生肠毒素（A、B、C）和中毒性休克毒素的情况进行了调查。在23株分离菌株中，有22株被发现具有产毒性：7株产生肠毒素A，8株产生肠毒素B，3株产生肠毒素C，13株产生中毒性休克毒素。在5例中发现中毒性休克毒素与肠毒素A同时存在，仅在1例中发现与肠毒素A和B同时存在。从患有除中毒性休克综合征以外疾病的患者阴道中分离出的46株金黄色葡萄球菌菌株中，63%产生毒素；其中8株产生中毒性休克毒素。
