Paris A L, Herwaldt L A, Blum D, Schmid G P, Shands K N, Broome C V
Ann Intern Med. 1982 Jun;96(6 Pt 2):852-7. doi: 10.7326/0003-4819-96-6-852.
Pathologic changes in 12 fatal cases of toxic shock syndrome occurred in the vagina, cervix, lung, liver, and kidney. Desquamation and ulceration of the cervical and vaginal mucosa were seen in all six cases where adequate specimens were submitted. Hyaline membrane formation characteristic of "shock lung" was found in all lung tissues. Periportal inflammation was found in all liver specimens and acute tubular necrosis was seen in eight of the 12 kidney specimens. Although not specific for toxic shock syndrome, the findings are consistent with the hypothesis that the illness is caused by a staphylococcal toxin.
12例中毒性休克综合征死亡病例的病理变化发生于阴道、宫颈、肺、肝和肾。在提交了足够标本的所有6例病例中，均可见宫颈和阴道黏膜的脱屑和溃疡。在所有肺组织中均发现了“休克肺”特有的透明膜形成。在所有肝标本中均发现汇管区炎症，12例肾标本中有8例出现急性肾小管坏死。尽管这些发现并非中毒性休克综合征所特有，但与该病由葡萄球菌毒素引起的假说相符。
