Yang Zehua, Zheng Yamei, Zhao Jie, Zhong Yi, Zhang Lei, Wu Haihong, Xie Tian, Ding Yipeng
Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
Department of General Practice, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
Respir Med. 2025 Feb;237:107923. doi: 10.1016/j.rmed.2024.107923. Epub 2024 Dec 27.
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. Interleukin-13 (IL13), associated with T-helper type 2 cells, plays a crucial role in COPD pathophysiology. This study aimed to investigate the relationship of single nucleotide polymorphisms (SNPs) in IL13 to COPD risk.
Five candidate SNPs of IL13 were genotyped using MassARRAY iPLEX platform in a cohort of472 COPD patients and 472 healthy controls. Logistic regression analysis was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs). Additionally, Multifactor dimensionality reduction (MDR) software was utilized to assess the combined impact of SNP-SNP interactions on COPD risk.
IL13 rs20541 (OR: 1.24, p: 0.028), rs1295685 (OR: 1.31, p: 0.006), rs848 (OR: 1.27, p: 0.016), and rs847 (OR: 1.30, p: 0.007) were associated with COPD risk. Moreover, IL13 variants were related to the increased COPD risk in females, individuals aged ≥68 year, non-smokers or non-drinkers. The optimal multi-locus model was identified as the combination of rs20541 and rs1295685.
Our findings indicated the association between IL13 variants and an elevated risk of developing COPD, especially rs1295685 and rs847. These findings could have implications for understanding the role of IL13 variants in COPD predisposition.
慢性阻塞性肺疾病（COPD）的特征为持续的呼吸道症状和气流受限。与2型辅助性T细胞相关的白细胞介素-13（IL13）在COPD病理生理学中起关键作用。本研究旨在探讨IL13单核苷酸多态性（SNP）与COPD风险的关系。
使用MassARRAY iPLEX平台对472例COPD患者和472例健康对照者组成的队列进行IL13的5个候选SNP基因分型。采用逻辑回归分析计算比值比（OR）和95%置信区间（CI）。此外，利用多因素降维（MDR）软件评估SNP-SNP相互作用对COPD风险的综合影响。
IL13 rs20541（OR：1.24，p：0.028）、rs1295685（OR：1.31，p：0.006）、rs848（OR：1.27，p：0.016）和rs847（OR：1.30，p：0.007）与COPD风险相关。此外，IL13变异与女性、年龄≥68岁、不吸烟者或不饮酒者中COPD风险增加有关。最佳多位点模型确定为rs20541和rs1295685的组合。
我们的研究结果表明IL13变异与COPD发生风险升高之间存在关联，尤其是rs1295685和rs847。这些发现可能有助于理解IL13变异在COPD易感性中的作用。
