Zhang Qi, Zhang Yingdan, Guo Shiyun, Wang Honggang
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167642. doi: 10.1016/j.bbadis.2024.167642. Epub 2024 Dec 27.
Hepatocellular carcinoma (HCC) is a major type of liver cancer and an important cause of cancer death. It has been reported that the hepatocyte death plays an important role in HCC. Ferroptosis is an iron-dependent programmed cell death characterized by the accumulation of free iron and lipid peroxidation. A series of studies have shown that ferroptosis contributes to the occurrence and development of HCC. MicroRNAs (miRNAs) are non-coding RNAs with a length of approximately 222 nt. In recent years, miRNAs have been shown to participate in regulating ferroptosis to play a vital role in HCC, but the related mechanisms are not fully understood. This review summarized the current understanding of ferroptosis, as well as the biogenesis and function of miRNAs, and focused on the role of miRNAs regulation of ferroptosis in HCC, with the hope of providing new targets and ideas for the treatment of HCC.
肝细胞癌（HCC）是肝癌的主要类型，也是癌症死亡的重要原因。据报道，肝细胞死亡在HCC中起重要作用。铁死亡是一种铁依赖性程序性细胞死亡，其特征是游离铁的积累和脂质过氧化。一系列研究表明，铁死亡促进了HCC的发生和发展。微小RNA（miRNA）是长度约为22个核苷酸的非编码RNA。近年来，miRNA已被证明参与调节铁死亡，在HCC中发挥至关重要的作用，但其相关机制尚未完全明确。本综述总结了目前对铁死亡以及miRNA的生物发生和功能的认识，并着重探讨了miRNA调节铁死亡在HCC中的作用，希望为HCC的治疗提供新的靶点和思路。
