Department of General Surgery, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China.
The First People's Hospital of Longquanyi District, Chengdu, China.
Front Immunol. 2024 May 23;15:1424954. doi: 10.3389/fimmu.2024.1424954. eCollection 2024.
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to the medical community because of its high mortality rate. In recent years, ferroptosis, a unique form of cell death, has garnered widespread attention. Ferroptosis, which is characterized by iron-dependent lipid peroxidation and mitochondrial alterations, is closely associated with the pathological processes of various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are a type of functional RNA, and play crucial regulatory roles in a variety of biological processes. In this manuscript, we review the regulatory roles of lncRNAs in the key aspects of ferroptosis, and summarize the research progress on ferroptosis-related lncRNAs in hepatocellular carcinoma.
肝细胞癌是原发性肝癌中最常见的一种形式，由于其高死亡率，对医学界构成了重大挑战。近年来，铁死亡作为一种独特的细胞死亡形式，引起了广泛关注。铁死亡的特征是铁依赖性脂质过氧化和线粒体改变，与包括肝细胞癌在内的各种疾病的病理过程密切相关。长链非编码 RNA（lncRNA）是一种具有功能的 RNA，在多种生物学过程中发挥关键的调节作用。在本手稿中，我们综述了 lncRNA 在铁死亡关键方面的调节作用，并总结了铁死亡相关 lncRNA 在肝细胞癌中的研究进展。
