Wang Shuxian, He Bo, Liu Huan, Muhammad Imran, Cai Jinzhen, Wang Feng
Organ Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Institute of Transplantation Science, The Affiliated Hospital of Qingdao University, Qingdao, China.
Transpl Immunol. 2025 Feb;88:102171. doi: 10.1016/j.trim.2024.102171. Epub 2024 Dec 27.
Cytomegalovirus (CMV) is a common clinical infection especially after organ transplantation and threaten the survival of recipients. Natural killer (NK) cells play an important role in the process of CMV infection. In this study, we want to explore that if the different of killer immunoglobulin-like receptors (KIRs) of NK cells could affect CMV infection.
We study a cohort of 447 recipients after liver transplantation in our center. KIR-SSO Genotyping kit was used to detect the activated and inhibitory KIR genes. We determine the high-risk factors for CMV infection, and based on the KIR genotype, the recipients are divided into different groups, then the rate of CMV infection was analyzed.
CMV infection occurred in 32/447 (7.2 %) patients in the first year after the transplant surgery. We find that recipient age, Body Mass Index (BMI), Model for End-Stage Liver Disease (MELD) score, intubation time, and occurrence of Early Allograft Dysfunction (EAD) are high-risk factors for CMV infection. Comparing with the CMV-DNA turned negative, the percentage of lymphocyte, as well as the number of lymphocytes and CD4 lymphocytes decreased when the period of receipts' CMV-DNA tested positive. The rate of CMV infection in Tel-B/X genotype group is significantly lower than A/A genotype group.
Our data indicates that KIR genes can affect CMV infection and provide potential clinical value following liver transplantation.
巨细胞病毒（CMV）是一种常见的临床感染，尤其是在器官移植后，会威胁受者的生存。自然杀伤（NK）细胞在CMV感染过程中起重要作用。在本研究中，我们想探讨NK细胞杀伤免疫球蛋白样受体（KIRs）的差异是否会影响CMV感染。
我们研究了本中心447例肝移植受者。使用KIR-SSO基因分型试剂盒检测激活和抑制性KIR基因。我们确定CMV感染的高危因素，并根据KIR基因型将受者分为不同组，然后分析CMV感染率。
32/447（7.2%）例患者在移植手术后第一年发生CMV感染。我们发现受者年龄、体重指数（BMI）、终末期肝病模型（MELD）评分、插管时间和早期移植物功能障碍（EAD）的发生是CMV感染的高危因素。与CMV-DNA转阴相比，受者CMV-DNA检测阳性期间淋巴细胞百分比以及淋巴细胞和CD4淋巴细胞数量减少。Tel-B/X基因型组的CMV感染率显著低于A/A基因型组。
我们的数据表明KIR基因可影响CMV感染，并为肝移植后的临床应用提供潜在价值。
