Xu Weilin, Yan Jun, Shao Anwen, Lenahan Cameron, Gao Liansheng, Wu Haijian, Zheng Jingwei, Zhang Jianmin, Zhang John H
Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, China.
Fundam Res. 2023 Jun 2;4(6):1389-1397. doi: 10.1016/j.fmre.2023.04.016. eCollection 2024 Nov.
Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system (CNS) in recent years. In this review, we comprehensively discussed the physiological and pathological mechanisms of peroxisomes and pexophagy in neurological diseases. Peroxisomes communicate with mitochondria, endoplasmic reticulum, and lipid bodies. Their types, sizes, and shapes vary in different regions of the brain. Moreover, peroxisomes play an important role in oxidative homeostasis, lipid synthesis, and degradation in the CNS, whereas its dysfunction causes various neurological diseases. Therefore, selective removal of dysfunctional or superfluous peroxisomes (pexophagy) provides neuroprotective effects, which indicate a promising therapeutic target. However, pexophagy largely remains unexplored in neurological disorders. More studies are needed to explore the pexophagy's crosstalk mechanisms in neurological pathology.
近年来，过氧化物酶体和过氧化物酶体自噬在中枢神经系统（CNS）中的作用越来越受到关注。在这篇综述中，我们全面讨论了过氧化物酶体和过氧化物酶体自噬在神经疾病中的生理和病理机制。过氧化物酶体与线粒体、内质网和脂滴相互作用。它们的类型、大小和形状在大脑的不同区域有所不同。此外，过氧化物酶体在中枢神经系统的氧化稳态、脂质合成和降解中起重要作用，而其功能障碍会导致各种神经疾病。因此，选择性清除功能失调或多余的过氧化物酶体（过氧化物酶体自噬）具有神经保护作用，这表明它是一个有前景的治疗靶点。然而，过氧化物酶体自噬在神经疾病中的研究在很大程度上仍未被探索。需要更多的研究来探索过氧化物酶体自噬在神经病理学中的相互作用机制。
