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Neuroinflammation in COVID-19: Fibrinogen (fibrin), a potential culprit!新冠病毒感染中的神经炎症:纤维蛋白原(纤维蛋白),一个潜在的罪魁祸首!
Med J Armed Forces India. 2024 Dec;80(Suppl 1):S407-S408. doi: 10.1016/j.mjafi.2023.07.008. Epub 2023 Oct 16.
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Fibrin-Targeting Immunotherapy for Dementia.纤维蛋白靶向免疫疗法治疗痴呆。
J Prev Alzheimers Dis. 2023;10(4):647-660. doi: 10.14283/jpad.2023.105.
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Inhibition of fibrin formation reduces neuroinflammation and improves long-term outcome after intracerebral hemorrhage.抑制纤维蛋白形成可减少脑出血后的神经炎症反应,改善长期预后。
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Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ peptide ameliorates neurological deficits after ischemic stroke.纤维蛋白原沉积促进神经炎症,纤维蛋白衍生的γ肽可改善缺血性脑卒中后的神经功能缺损。
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Fibrin induces infiltration of macrophages and neutrophils via integrin αMβ2 and triggers aortic dissection.纤维蛋白通过整合素αMβ2诱导巨噬细胞和中性粒细胞浸润,并引发主动脉夹层。
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Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19.新型冠状病毒病中的纤维蛋白原、纤维蛋白和纤维蛋白降解产物。
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The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm.纤维蛋白衍生肽FX06可保护人肺内皮细胞免受新冠病毒引发的细胞因子风暴的影响。
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Binding of a new monoclonal antibody against N-terminal heptapeptide of fibrin alpha-chain to fibrin polymerization site 'A': effects of fibrinogen and fibrinogen derivatives, and pretreatment of samples with NaSCN.一种针对纤维蛋白α链N端七肽的新型单克隆抗体与纤维蛋白聚合位点“A”的结合:纤维蛋白原和纤维蛋白原衍生物的影响,以及用硫氰酸钠对样品进行预处理
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Fibrin self-assembly is adapted to oxidation.纤维蛋白自组装适应氧化作用。
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Fibrin drives thromboinflammation and neuropathology in COVID-19.纤维蛋白导致 COVID-19 中的血栓炎症和神经病理学。
Nature. 2024 Sep;633(8031):905-913. doi: 10.1038/s41586-024-07873-4. Epub 2024 Aug 28.

本文引用的文献

1
Neurobiology of long-COVID: Hypotheses and unanswered questions.长新冠的神经生物学:假说与未解之谜
Anaesth Crit Care Pain Med. 2023 Jun;42(3):101201. doi: 10.1016/j.accpm.2023.101201. Epub 2023 Feb 15.
2
Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle?血浆纤维蛋白原:是解开新冠重症监护病房谵妄谜团的重要一环?
Med Hypotheses. 2022 Nov;168:110953. doi: 10.1016/j.mehy.2022.110953. Epub 2022 Sep 21.
3
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system.长新冠/COVID-19 后急性后遗症(PASC)中纤维蛋白原纤维微血栓的蛋白质组学研究表明,其中有许多被捕获的促炎分子,这也可能导致纤溶系统失效。
Cardiovasc Diabetol. 2022 Sep 21;21(1):190. doi: 10.1186/s12933-022-01623-4.
4
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications.在长新冠/后新冠长期症状中,淀粉样纤维微栓子发挥核心作用:起源和治疗意义。
Biochem J. 2022 Feb 17;479(4):537-559. doi: 10.1042/BCJ20220016.
5
Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin.长期 COVID/COVID-19 后急性后遗症(PASC)中持续存在的凝血蛋白病理学伴随着抗纤溶酶水平的升高。
Cardiovasc Diabetol. 2021 Aug 23;20(1):172. doi: 10.1186/s12933-021-01359-7.
6
Impending cognitive and functional decline in COVID-19 survivors. Comment on Br J Anaesth 2021; 126: 44-7.新冠病毒疾病幸存者即将出现的认知和功能衰退。对《英国麻醉学杂志》2021年;126卷:44 - 7页的评论
Br J Anaesth. 2021 Mar;126(3):e113-e114. doi: 10.1016/j.bja.2020.12.009. Epub 2020 Dec 9.
7
Fibrinogen and Neuroinflammation During Traumatic Brain Injury.创伤性脑损伤期间的纤维蛋白原和神经炎症。
Mol Neurobiol. 2020 Nov;57(11):4692-4703. doi: 10.1007/s12035-020-02012-2. Epub 2020 Aug 10.
8
Fibrinogen and risk of dementia: A systematic review and meta-analysis.纤维蛋白原与痴呆风险:系统评价和荟萃分析。
Neurosci Biobehav Rev. 2020 May;112:353-360. doi: 10.1016/j.neubiorev.2020.02.022. Epub 2020 Feb 17.
9
Inhibition of fibrin formation reduces neuroinflammation and improves long-term outcome after intracerebral hemorrhage.抑制纤维蛋白形成可减少脑出血后的神经炎症反应,改善长期预后。
Int Immunopharmacol. 2019 Jul;72:473-478. doi: 10.1016/j.intimp.2019.04.029. Epub 2019 Apr 28.
10
Development, maintenance and disruption of the blood-brain barrier.血脑屏障的发育、维持和破坏。
Nat Med. 2013 Dec;19(12):1584-96. doi: 10.1038/nm.3407. Epub 2013 Dec 5.

Neuroinflammation in COVID-19: Fibrinogen (fibrin), a potential culprit!

作者信息

Magoon Rohan, Mahajan Shalvi

机构信息

Assistant Professor (Anaesthesia), Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Assistant Professor (Anaesthesia & Intensive Care), PGIMER, Chandigarh, India.

出版信息

Med J Armed Forces India. 2024 Dec;80(Suppl 1):S407-S408. doi: 10.1016/j.mjafi.2023.07.008. Epub 2023 Oct 16.

DOI:10.1016/j.mjafi.2023.07.008
PMID:39734898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11670567/
Abstract
摘要