Neuroinflammation in COVID-19: Fibrinogen (fibrin), a potential culprit!
作者信息
Magoon Rohan, Mahajan Shalvi
机构信息
Assistant Professor (Anaesthesia), Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) & Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Assistant Professor (Anaesthesia & Intensive Care), PGIMER, Chandigarh, India.
出版信息
Med J Armed Forces India. 2024 Dec;80(Suppl 1):S407-S408. doi: 10.1016/j.mjafi.2023.07.008. Epub 2023 Oct 16.
Abstract
摘要
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本文引用的文献
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Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle?血浆纤维蛋白原：是解开新冠重症监护病房谵妄谜团的重要一环？
Med Hypotheses. 2022 Nov;168:110953. doi: 10.1016/j.mehy.2022.110953. Epub 2022 Sep 21.
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Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system.长新冠/COVID-19 后急性后遗症（PASC）中纤维蛋白原纤维微血栓的蛋白质组学研究表明，其中有许多被捕获的促炎分子，这也可能导致纤溶系统失效。
Cardiovasc Diabetol. 2022 Sep 21;21(1):190. doi: 10.1186/s12933-022-01623-4.
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A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications.在长新冠/后新冠长期症状中，淀粉样纤维微栓子发挥核心作用：起源和治疗意义。
Biochem J. 2022 Feb 17;479(4):537-559. doi: 10.1042/BCJ20220016.
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Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin.长期 COVID/COVID-19 后急性后遗症（PASC）中持续存在的凝血蛋白病理学伴随着抗纤溶酶水平的升高。
Cardiovasc Diabetol. 2021 Aug 23;20(1):172. doi: 10.1186/s12933-021-01359-7.
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Impending cognitive and functional decline in COVID-19 survivors. Comment on Br J Anaesth 2021; 126: 44-7.新冠病毒疾病幸存者即将出现的认知和功能衰退。对《英国麻醉学杂志》2021年；126卷：44 - 7页的评论
Br J Anaesth. 2021 Mar;126(3):e113-e114. doi: 10.1016/j.bja.2020.12.009. Epub 2020 Dec 9.
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Mol Neurobiol. 2020 Nov;57(11):4692-4703. doi: 10.1007/s12035-020-02012-2. Epub 2020 Aug 10.
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Neurosci Biobehav Rev. 2020 May;112:353-360. doi: 10.1016/j.neubiorev.2020.02.022. Epub 2020 Feb 17.
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Inhibition of fibrin formation reduces neuroinflammation and improves long-term outcome after intracerebral hemorrhage.抑制纤维蛋白形成可减少脑出血后的神经炎症反应，改善长期预后。
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Development, maintenance and disruption of the blood-brain barrier.血脑屏障的发育、维持和破坏。
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