The Effect of Fluoroquinolones on Aortic Aneurysm and Dissection.

Fluoroquinolones (FQs) are a widely prescribed class of antibiotics including ciprofloxacin, levofloxacin, and ofloxacin. They are commonly used to treat a variety of infections worldwide. Known for their broad-spectrum antimicrobial activity, as well as excellent pharmacokinetics and bioavailability, the use of FQs has risen significantly. While generally well-tolerated, research has indicated that FQs may aggravate collagen-related disorders. These antibiotics increase the activity of matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, which degrade type I collagen, weakening the structural integrity of tendons. Some studies have demonstrated the association between FQs and the risk of aortic aneurysm or dissection. Given the life-threatening nature of these conditions, these findings are particularly concerning.