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本文引用的文献

1
Oral fluoroquinolones and risk of aortic aneurysm or dissection: A nationwide population-based propensity score-matched cohort study.口服氟喹诺酮类药物与主动脉瘤或夹层的风险：一项基于全国人群的倾向评分匹配队列研究。
Pharmacotherapy. 2023 Sep;43(9):883-893. doi: 10.1002/phar.2841. Epub 2023 Jul 11.
2
Association of Fluoroquinolone Use With Short-term Risk of Development of Aortic Aneurysm.氟喹诺酮类药物的使用与主动脉瘤短期发病风险的关联。
JAMA Surg. 2021 Mar 1;156(3):264-272. doi: 10.1001/jamasurg.2020.6165.
3
Association of Infections and Use of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection.感染和氟喹诺酮类药物的使用与主动脉瘤或主动脉夹层风险的关联。
JAMA Intern Med. 2020 Dec 1;180(12):1587-1595. doi: 10.1001/jamainternmed.2020.4192.
4
Fluoroquinolones and the Risk of Aortic Aneurysm or Aortic Dissection: A Systematic Review and Meta-Analysis.氟喹诺酮类药物与主动脉瘤或主动脉夹层风险：一项系统评价和荟萃分析
Cardiovasc Hematol Agents Med Chem. 2019;17(1):3-10. doi: 10.2174/1871525717666190402121958.
5
Impact of age, sex, obesity, and steroid use on quinolone-associated tendon disorders.年龄、性别、肥胖和类固醇使用对喹诺酮类药物相关肌腱疾病的影响。
Am J Med. 2012 Dec;125(12):1228.e23-1228.e28. doi: 10.1016/j.amjmed.2012.05.027. Epub 2012 Sep 28.

氟喹诺酮类药物对主动脉瘤和主动脉夹层的影响。

The Effect of Fluoroquinolones on Aortic Aneurysm and Dissection.

作者信息

Morales-Ojeda Luis A

机构信息

Vascular Surgery, University of Colorado Anschutz Medical Center, Colorado, USA.

出版信息

Cureus. 2024 Nov 29;16(11):e74740. doi: 10.7759/cureus.74740. eCollection 2024 Nov.

DOI:10.7759/cureus.74740
PMID:39735091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11682837/
Abstract

Fluoroquinolones (FQs) are a widely prescribed class of antibiotics including ciprofloxacin, levofloxacin, and ofloxacin. They are commonly used to treat a variety of infections worldwide. Known for their broad-spectrum antimicrobial activity, as well as excellent pharmacokinetics and bioavailability, the use of FQs has risen significantly. While generally well-tolerated, research has indicated that FQs may aggravate collagen-related disorders. These antibiotics increase the activity of matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, which degrade type I collagen, weakening the structural integrity of tendons. Some studies have demonstrated the association between FQs and the risk of aortic aneurysm or dissection. Given the life-threatening nature of these conditions, these findings are particularly concerning.

摘要

氟喹诺酮类（FQs）是一类广泛应用的抗生素，包括环丙沙星、左氧氟沙星和氧氟沙星。它们在全球范围内常用于治疗多种感染。氟喹诺酮类以其广谱抗菌活性以及出色的药代动力学和生物利用度而闻名，其使用量已显著增加。虽然通常耐受性良好，但研究表明氟喹诺酮类可能会加重与胶原蛋白相关的疾病。这些抗生素会增加基质金属蛋白酶（MMPs）的活性，尤其是MMP - 2和MMP - 9，它们会降解I型胶原蛋白，削弱肌腱的结构完整性。一些研究已经证明了氟喹诺酮类与主动脉瘤或夹层风险之间的关联。鉴于这些疾病危及生命的性质，这些发现尤其令人担忧。