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《好好处理：一例维生素B12缺乏与脊髓亚急性联合变性》

Whip It Good: A Case of Vitamin B12 Deficiency and Subacute Combined Degeneration of the Spinal Cord.

作者信息

Pourshams Idean A, Arora Manik, Nimkar Santosh, Kumbham Pradeep

机构信息

Internal Medicine, University of Arkansas for Medical Sciences, Fayetteville, USA.

Neurology, Osteopathic Medical School, Kansas City University, Kansas City, USA.

出版信息

Cureus. 2024 Nov 27;16(11):e74620. doi: 10.7759/cureus.74620. eCollection 2024 Nov.

DOI:10.7759/cureus.74620
PMID:39735103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11682698/
Abstract

A 40-year-old male patient with no significant past history presented to the emergency room with bilateral upper and lower extremity numbness and difficulty walking for three weeks. MRI of the thoracic spine revealed cord signal abnormalities in the dorsal columns consistent with selective degeneration. This was congruent with the patient's presentation and symptoms of myelopathy with dorsal column involvement along with peripheral polyneuropathy. Nitrous oxide inhalation was the culprit, causing acute vitamin B12 deficiency and subsequent myeloneuropathies.

摘要

一名40岁男性患者，既往史无特殊，因双侧上下肢麻木及行走困难3周就诊于急诊室。胸椎MRI显示脊髓后索信号异常，符合选择性变性。这与患者的表现及脊髓病症状相符，伴有后索受累及周围性多发性神经病。一氧化二氮吸入是罪魁祸首，导致急性维生素B12缺乏及随后的脊髓神经病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cb/11682698/ac8b400b64ad/cureus-0016-00000074620-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cb/11682698/3496d4be2e8b/cureus-0016-00000074620-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cb/11682698/6823e30f7176/cureus-0016-00000074620-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cb/11682698/ac8b400b64ad/cureus-0016-00000074620-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cb/11682698/3496d4be2e8b/cureus-0016-00000074620-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cb/11682698/6823e30f7176/cureus-0016-00000074620-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9cb/11682698/ac8b400b64ad/cureus-0016-00000074620-i03.jpg

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本文引用的文献

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Laughing with serious consequences- a case report of recreational laughing gas use with functional vitamin B12 deficiency.因笑引发严重后果——一例关于娱乐性使用笑气导致功能性维生素B12缺乏的病例报告
Clin Med (Lond). 2023 Nov;23(Suppl 6):61. doi: 10.7861/clinmed.23-6-s61.
2
From Medical Analgesic to Recreational Use: A Rare Case of Acute Myelitis Caused by Laughing Gas Abuse.从医用镇痛剂到娱乐性使用：一例罕见的因滥用笑气导致急性脊髓炎的病例。
Cureus. 2023 Jun 27;15(6):e41018. doi: 10.7759/cureus.41018. eCollection 2023 Jun.
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Mechanisms Involved in the Neurotoxicity and Abuse Liability of Nitrous Oxide: A Narrative Review.
一氧化二氮的神经毒性和滥用倾向的作用机制：叙述性综述。
Int J Mol Sci. 2022 Nov 25;23(23):14747. doi: 10.3390/ijms232314747.
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Recreational use of nitrous oxide.氧化亚氮的娱乐性使用。
BMJ. 2022 Sep 27;378:o2297. doi: 10.1136/bmj.o2297.
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Nitrous Oxide-Induced Vitamin B12 Deficiency Resulting in Myelopathy.一氧化二氮所致维生素B12缺乏导致脊髓病。
Cureus. 2020 Jul 9;12(7):e9088. doi: 10.7759/cureus.9088.
6
Subacute Combined Spinal Cord Degeneration by Recreational Laughing Gas (NO) Use.因使用娱乐性笑气（一氧化二氮）导致的亚急性联合变性脊髓病
J Cent Nerv Syst Dis. 2019 Mar 26;11:1179573519838277. doi: 10.1177/1179573519838277. eCollection 2019.
7
Mini-Review: A Brief History of Nitrous Oxide (N2O) Use in Neuropsychiatry.综述：一氧化二氮（N₂O）在神经精神病学中的应用简史
Curr Drug Res Rev. 2019;11(1):12-20. doi: 10.2174/1874473711666181008163107.
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Up: The rise of nitrous oxide abuse. An international survey of contemporary nitrous oxide use.向上：一氧化二氮滥用的兴起。当代一氧化二氮使用情况的国际调查。
J Psychopharmacol. 2016 Apr;30(4):395-401. doi: 10.1177/0269881116632375. Epub 2016 Feb 24.
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