Gurgel Sofia Emerenciano, de Medeiros Kleyton Santos, Lima de Paiva Sarah Jane, Gurgel Filho José
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Instituto de Ensino, Pesquisa e Inovação, Liga Contra o Câncer, Natal, Rio Grande do Norte, Brazil.
Case Rep Med. 2024 Dec 19;2024:2666671. doi: 10.1155/carm/2666671. eCollection 2024.
The case involves a 63-year-old hypertensive man, taking antihypertensive medication (olmesartan) for the previous two years, who sought medical attention due to voluminous diarrhea, with several episodes per day and weight loss of 10 kg. He was submitted to a series of diagnostic procedures without elucidation and empirical treatment with unsuccessful outcome. After hospitalization for clinical stabilization and for presenting with duodenal atrophy, obtained by duodenal biopsy associated with negative markers for celiac disease, the patient was diagnosed with suspected olmesartan-induced enteropathy, showing rapid improvement of diarrhea after the drug was withdrawn, with weight regain in 6 months and normalization of the duodenal histological picture after 10 months.
该病例涉及一名63岁的高血压男性，此前两年一直在服用抗高血压药物（奥美沙坦），因腹泻量大而就医，每天发作数次，体重减轻10公斤。他接受了一系列诊断程序，但未明确病因，经验性治疗也未成功。在住院以实现临床稳定并因十二指肠活检显示十二指肠萎缩且乳糜泻标志物为阴性后，该患者被诊断为疑似奥美沙坦诱导的肠病，停药后腹泻迅速改善，6个月后体重恢复，10个月后十二指肠组织学图像恢复正常。
