Yaghini Jaber, Mogharehabed Ahmad, Feizi Awat, Yazdanfar Fatemeh
Department of Periodontology, Dental Implant Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2024 Nov 26;21:63. doi: 10.4103/drj.drj_437_22. eCollection 2024.
This systematic review and meta-analysis aimed to assess the efficacy of autologous platelet concentrate (APCs) in comparison with coronally-advanced flap alone or in combination with connective tissue graft or other biomaterials or bioactive agents for root coverage (RC) of Miller's Class I and II gingival recession defects by measuring the keratinized mucosa width (KMW).
This systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines. An electronic search of the literature was conducted in PubMed, EMBASE, Scopus, Cochrane, Web of Science, Magiran, Scientific Information Database, and Irandoc for randomized clinical trials (RCTs) that used APCs for RC in their intervention group. Eligible articles were retrieved by assessment of titles and abstracts and then the full texts. The risk of bias was assessed by the Cochrane Library Risk of Bias Assessment Tool. Meta-analysis was carried out by RevMan 5.3 software. In the case of homogeneity, variables were reported as weighted mean difference (WMD) with 95% confidence interval (CI) for each group.
The search yielded 689 articles; out of which, 32 were eligible for study inclusion. Meta-analysis did not show any additional effect for RC and KMW with APCs. Clinical parameters were as follows: RC: WMD = -1.57 mm (95% CI: -2.49, -0.659; = 0.001) and KMW: -0.106 mm (95% CI: -0.3222, 0.110; = 0.337).
The application of APCs for RC of Miller's Class I and II gingival recession defects does not seem to improve the clinical parameters.
本系统评价和荟萃分析旨在通过测量角化黏膜宽度（KMW），评估自体血小板浓缩物（APCs）与单纯冠向推进瓣或与结缔组织移植或其他生物材料或生物活性剂联合使用相比，用于米勒I类和II类牙龈退缩缺损的根面覆盖（RC）的疗效。
本系统评价和荟萃分析按照系统评价和荟萃分析指南的首选报告项目进行。在PubMed、EMBASE、Scopus、Cochrane、科学引文索引、Magiran、科学信息数据库和伊朗文献数据库中对文献进行电子检索，以查找在干预组中使用APCs进行根面覆盖的随机临床试验（RCTs）。通过标题和摘要评估检索合格文章，然后获取全文。采用Cochrane图书馆偏倚风险评估工具评估偏倚风险。使用RevMan 5.3软件进行荟萃分析。在存在同质性的情况下，将变量报告为每组的加权平均差（WMD）及其95%置信区间（CI）。
检索到689篇文章；其中32篇符合纳入研究标准。荟萃分析未显示APCs对根面覆盖和角化黏膜宽度有任何额外影响。临床参数如下：根面覆盖：WMD = -1.57 mm（95% CI：-2.49，-0.659；P = 0.001），角化黏膜宽度：-0.106 mm（95% CI：-0.3222，0.110；P = 0.337）。
应用APCs治疗米勒I类和II类牙龈退缩缺损似乎并未改善临床参数。
