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用于冠向推进瓣术辅助的生物材料的稳定性：系统评价和网络荟萃分析。

Stability of biomaterials used in adjunct to coronally advanced flap: A systematic review and network meta-analysis.

机构信息

Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India.

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

出版信息

Clin Exp Dent Res. 2022 Feb;8(1):421-438. doi: 10.1002/cre2.461. Epub 2021 Nov 29.

DOI:10.1002/cre2.461
PMID:34845864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8874057/
Abstract

AIM

The objective of this network meta-analysis was to rank different biomaterials used in adjunct to coronally advanced flap (CAF), based on their performance in root-coverage for Miller's Class I and II gingival recessions.

MATERIALS AND METHODS

An electronic database search was carried out in PUBMED, CENTRAL, SCOPUS, and EMBASE to identify the eligible articles and compiled into the citation manager to remove the duplicates. The primary outcome was keratinized gingival tissue width (KGW) and percentage of root coverage (%RC). The treatment effect of different biomaterials was estimated using predictive interval plots and ranked based on biomaterials performance, using multidimensional scale ranking.

RESULTS

CAF + connective tissue graft (CTG), CAF + platelet concentrate matrix (PCM) and acellular dermal matrix (ADM) ranked at the top positions in performance in improving KGW. The highest ranked materials in improving percentage of root coverage in gingival recession were CAF + collagen matrix (CM) + gingival fibroblasts (GF), CAF + ADM + platelet rich plasma (PRP) and CAF + ADM, as compared to CAF alone.

CONCLUSION

CTG, ADM, platelet concentrates, and CM + GFs, when used in adjunct to CAF, showed improved stability over ≥12 months of follow-up, better percentage of root coverage, and improved keratinized gingival width.

摘要

目的

本网状荟萃分析旨在根据不同生物材料在附加于冠向推进瓣（CAF）后用于Miller Ⅰ类和Ⅱ类牙龈退缩的根面覆盖中的表现，对其进行排序。

材料和方法

在 PUBMED、CENTRAL、SCOPUS 和 EMBASE 中进行电子数据库检索，以确定合格的文章，并将其编译到引文管理器中以去除重复项。主要结局为角化龈组织宽度（KGW）和根面覆盖率（%RC）。使用预测区间图估计不同生物材料的治疗效果，并根据生物材料性能使用多维尺度排名进行排名。

结果

CAF+结缔组织移植物（CTG）、CAF+血小板浓缩物基质（PCM）和脱细胞真皮基质（ADM）在改善 KGW 方面的表现排名靠前。在改善牙龈退缩处根面覆盖率方面排名最高的材料是 CAF+胶原基质（CM）+牙龈成纤维细胞（GF）、CAF+ADM+富血小板血浆（PRP）和 CAF+ADM，与单独使用 CAF 相比。

结论

与单独使用 CAF 相比，在 CAF 附加使用 CTG、ADM、血小板浓缩物和 CM+GFs 可在 12 个月以上的随访中显示出更好的稳定性、更高的根面覆盖率和改善的角化龈宽度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/600a1d8666cb/CRE2-8-421-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/b387e0399a49/CRE2-8-421-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/710d1699dc01/CRE2-8-421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/0e90ccdd6602/CRE2-8-421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/4a61b6a78db8/CRE2-8-421-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/086b71c803d3/CRE2-8-421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/72e42dcb2275/CRE2-8-421-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/0b63c24041e8/CRE2-8-421-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/fca638417432/CRE2-8-421-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/5b95b46986b0/CRE2-8-421-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/600a1d8666cb/CRE2-8-421-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/b387e0399a49/CRE2-8-421-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/710d1699dc01/CRE2-8-421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/0e90ccdd6602/CRE2-8-421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/4a61b6a78db8/CRE2-8-421-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/086b71c803d3/CRE2-8-421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/72e42dcb2275/CRE2-8-421-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/0b63c24041e8/CRE2-8-421-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/fca638417432/CRE2-8-421-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/5b95b46986b0/CRE2-8-421-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd3a/8874057/600a1d8666cb/CRE2-8-421-g010.jpg

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