Vukovic M, Albijanic M, Radovic N
Department of Urology, Clinical Centre of Montenegro, Ljubljanska bb, 81000, Podgorica, Montenegro.
Urol Case Rep. 2024 Dec 5;58:102899. doi: 10.1016/j.eucr.2024.102899. eCollection 2025 Jan.
We present a case of a 66-year-old man with a three-year history of Gleason 10 prostate cancer (PCa), who presented with penile pain, erythema, and induration of the penile shaft. His cancer was treated with androgen deprivation therapy (ADT), radiotherapy, and apalutamide, resulting in PSA reduction; however, a solitary penile lesion persisted, necessitating radical penectomy. At 12 months post-surgery, PSA levels and magnetic resonance imaging findings remained stable, with no signs of metastasis. This case highlights the viability of radical penectomy for solitary penile metastasis in hormone-sensitive metastatic prostate cancer (mHSPC), with potential benefits for symptom control and survival.
我们报告一例66岁男性，患有格里森10分前列腺癌（PCa）三年，出现阴茎疼痛、红斑和阴茎硬结。他的癌症接受了雄激素剥夺治疗（ADT）、放疗和阿帕鲁胺治疗，导致前列腺特异性抗原（PSA）降低；然而，一个孤立的阴茎病变持续存在，需要进行根治性阴茎切除术。术后12个月，PSA水平和磁共振成像结果保持稳定，无转移迹象。该病例突出了根治性阴茎切除术对于激素敏感性转移性前列腺癌（mHSPC）中孤立性阴茎转移的可行性，对症状控制和生存可能有益。
