Wang Huimei, Li Shuo, Zhang Luping, Zhang Nan
Department of Gastroenterology, The First Hospital of Jilin University, Changchun, China.
Front Endocrinol (Lausanne). 2024 Dec 13;15:1469165. doi: 10.3389/fendo.2024.1469165. eCollection 2024.
In contemporary microbial research, the exploration of interactions between microorganisms and multicellular hosts constitutes a burgeoning field. The gut microbiota is increasingly acknowledged as a pivotal contributor to various disorders within the endocrine system, encompassing conditions such as diabetes and thyroid diseases. A surge in research activities has been witnessed in recent years, elucidating the intricate interplay between the gut microbiota and disorders of the endocrine system. Simultaneously, fecal microbiota transplantation (FMT) has emerged as a focal point, garnering substantial attention in both biomedical and clinical spheres. Research endeavors have uncovered the remarkable therapeutic efficacy of FMT across diverse diseases, with particular emphasis on its application in addressing type 2 diabetes mellitus (T2DM) and associated com-plications. Consequently, this manuscript accentuates the intimate connection between the gut microbiota and disorders within the endocrine system, with a specific focus on exploring the potential of FMT as an intervention in the therapeutic landscape of T2DM and its complications. Furthermore, the article scrutinizes concerns inherent in treatment modalities centered around the gut microbiota, proposing viable solutions to address these issues.
在当代微生物研究中,对微生物与多细胞宿主之间相互作用的探索构成了一个蓬勃发展的领域。肠道微生物群越来越被认为是内分泌系统各种疾病的关键促成因素,包括糖尿病和甲状腺疾病等病症。近年来,研究活动激增,阐明了肠道微生物群与内分泌系统疾病之间的复杂相互作用。同时,粪便微生物群移植(FMT)已成为一个焦点,在生物医学和临床领域都备受关注。研究工作已经揭示了FMT对多种疾病具有显著的治疗效果,尤其强调其在治疗2型糖尿病(T2DM)及其相关并发症方面的应用。因此,本手稿强调了肠道微生物群与内分泌系统疾病之间的密切联系,特别关注探索FMT作为T2DM及其并发症治疗领域干预措施的潜力。此外,本文审视了围绕肠道微生物群的治疗方式中固有的问题,提出了解决这些问题的可行方案。