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有包膜痘苗病毒在体内从小鼠鼻上皮细胞的细胞外释放

Extracellular release of enveloped vaccinia virus from mouse nasal epithelial cells in vivo.

作者信息

Payne L G, Kristensson K

出版信息

J Gen Virol. 1985 Mar;66 ( Pt 3):643-6. doi: 10.1099/0022-1317-66-3-643.

DOI:10.1099/0022-1317-66-3-643
PMID:3973566
Abstract

The release of vaccinia virus from mouse nasal epithelial cells infected in vivo was studied by electron microscopy. Intracellular naked vaccinia virus was enwrapped by Golgi membranes to form a double membrane intermediate. The outer membrane of the intermediate presumably fused with the plasma membrane, releasing extracellular enveloped virus. No signs of simple naked virus budding at the plasma membrane were observed. The majority of extracellular virus was enveloped and not naked.

摘要

通过电子显微镜研究了痘苗病毒从体内感染的小鼠鼻上皮细胞中的释放情况。细胞内的裸痘苗病毒被高尔基体膜包裹形成双膜中间体。该中间体的外膜可能与质膜融合，释放出细胞外被膜病毒。未观察到质膜处有简单裸病毒出芽的迹象。大多数细胞外病毒是有被膜的而非裸露的。

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