氨基丁酸可显著增加大鼠海马体内的细胞外牛磺酸水平。

Aminobutyric acid greatly increases the in vivo extracellular taurine in the rat hippocampus.

作者信息

Lerma J, Herranz A S, Herreras O, Muñoz D, Solís J M, del Río R M, Delgado J M

出版信息

J Neurochem. 1985 Mar;44(3):983-6. doi: 10.1111/j.1471-4159.1985.tb12913.x.

DOI:10.1111/j.1471-4159.1985.tb12913.x

Abstract

The effects of gamma-aminobutyric acid (GABA) on the extracellular levels of taurine and on excitability in the dentate gyrus were studied in anesthetized rats by the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode with Krebs-Ringer-bicarbonate or GABA solutions. Amino acid contents in perfusates and dentate field potentials evoked by electrical stimulation of the perforant pathway were evaluated. GABA drastically elevated the levels of extracellular taurine in a dose-dependent manner, decreasing the amplitude of the population spike. This result indicates that GABA stimulates taurine release, probably by a counter-transport process. It is suggested that in physiological conditions an increase in extracellular taurine may be produced by synaptically released GABA.

摘要

采用透析电极技术，在麻醉大鼠中研究了γ-氨基丁酸（GABA）对齿状回中牛磺酸细胞外水平及兴奋性的影响。通过透析电极用 Krebs-林格碳酸氢盐溶液或 GABA 溶液灌注齿状回。评估了灌注液中的氨基酸含量以及由穿通通路电刺激诱发的齿状场电位。GABA 以剂量依赖的方式显著提高细胞外牛磺酸水平，同时降低群体峰电位的幅度。该结果表明，GABA 可能通过反向转运过程刺激牛磺酸释放。提示在生理条件下，突触释放的 GABA 可能导致细胞外牛磺酸增加。