DL-炔丙基甘氨酸处理的大鼠脑不同区域中胱硫醚的积累。
Cystathionine accumulation in various regions of brain of DL-propargylglycine-treated rats.
作者信息
Kodama H, Ikeda H, Awata S, Nakayama K
出版信息
J Neurochem. 1985 Apr;44(4):1207-9. doi: 10.1111/j.1471-4159.1985.tb08744.x.
The contents of cystathionine and taurine, as well as cystathionine beta-synthase activity in various regions of the brains of normal and DL-propargylglycine-treated rats, were measured. The content of cystathionine in each region of brain increased gradually from 0.5 mg to 20 mg/200 g body weight in relation to the dose of DL-propargylglycine. Cystathionine was found to be unevenly distributed in brains of both normal and DL-propargylglycine-treated rats. On the other hand, the activity of cystathionine beta-synthase was evenly distributed in various regions of normal rat brain, and was unaltered following treatment of rats with DL-propargylglycine. The concentration of taurine was similarly unaffected by DL-propargylglycine injection.
对正常大鼠和经DL-炔丙基甘氨酸处理的大鼠大脑不同区域中的胱硫醚和牛磺酸含量以及胱硫醚β-合酶活性进行了测定。大脑各区域中胱硫醚的含量随着DL-炔丙基甘氨酸剂量的增加，从0.5毫克/200克体重逐渐增加到20毫克/200克体重。胱硫醚在正常大鼠和经DL-炔丙基甘氨酸处理的大鼠大脑中分布不均。另一方面，胱硫醚β-合酶活性在正常大鼠大脑的不同区域中分布均匀，在用DL-炔丙基甘氨酸处理大鼠后该活性未发生改变。牛磺酸的浓度同样不受DL-炔丙基甘氨酸注射的影响。
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