苯甲酸雌二醇反复给药对雄性大鼠结节-漏斗部γ-氨基丁酸能活性的影响。

Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male rats.

作者信息

Nicoletti F, Grandison L, Meek J L

出版信息

J Neurochem. 1985 Apr;44(4):1217-20. doi: 10.1111/j.1471-4159.1985.tb08746.x.

DOI:10.1111/j.1471-4159.1985.tb08746.x

Abstract

Repeated (once a day for 8 days) but not single administration of estradiol benzoate (10 micrograms/kg, s.c.) induced a sevenfold increase in anterior pituitary gamma-aminobutyric acid (GABA) concentration in male rats. GABA concentration also increased in the median eminence whereas no changes or decreases were observed in other brain regions including hypothalamic arcuate nucleus, lateral septum, hippocampus, caudate nucleus, and substantia nigra. Eight-day estradiol benzoate injection also enhanced the Vmax of median eminence glutamate decarboxylase activity without affecting the Km of the enzyme for glutamic acid. Taken together, these results suggest that repeated administration of estradiol benzoate increases the activity of the tubero-infundibular GABAergic system in male rats.

摘要

苯甲酸雌二醇（10微克/千克，皮下注射）重复给药（每天一次，共8天）而非单次给药可使雄性大鼠垂体前叶γ-氨基丁酸（GABA）浓度增加7倍。正中隆起处的GABA浓度也升高，而在包括下丘脑弓状核、外侧隔、海马、尾状核和黑质在内的其他脑区未观察到变化或降低。连续8天注射苯甲酸雌二醇还增强了正中隆起谷氨酸脱羧酶活性的最大反应速度（Vmax），而不影响该酶对谷氨酸的米氏常数（Km）。综上所述，这些结果表明，重复给予苯甲酸雌二醇可增加雄性大鼠结节-漏斗部GABA能系统的活性。