Booth Michael, Sabacinski Kenneth, Watkins Colleen, Butcho Erin, Kramer Emilie, Meadows Lukas, Bramer Michelle A
Department of Orthopaedics, West Virginia University, Morgantown, WV, USA.
Department of Neuroradiology, West Virginia University, Morgantown, WV, USA.
J Trauma Inj. 2024 Dec;37(4):276-280. doi: 10.20408/jti.2024.0038. Epub 2024 Dec 26.
The goal of this cross-sectional study was to investigate the prevalence of vitamin D deficiency in young orthopedic trauma patients and its impact on bone mineral density (BMD) measured through computed tomography imaging of the lumbar spine.
Conducted at a level I trauma center, this prospective cross-sectional analysis included 100 patients aged 18 to 50 years with non-fragility fractures. Vitamin D levels and Hounsfield units of the lumbar spine were recorded from computed tomography scans. Exclusion criteria included fragility fractures, lumbar surgery history, or lumbar bony/metastatic lesions. The correlation between vitamin D levels and BMD was assessed; vitamin D deficiency was defined as below 30 ng/mL.
Among the participants, 75% were vitamin D-deficient, with an average vitamin D level of 25.0 ng/mL. No patients had osteoporosis based on Hounsfield units; however, 5% of patients were in the osteopenic range. In patients with normal vitamin D levels, there was an inverse correlation between vitamin D levels and BMD measured by Hounsfield units (P=0.025). Higher lumbar spine Hounsfield unit measurements correlated with lower vitamin D levels in this nondeficient population.
This study highlights a high prevalence of vitamin D deficiency in young orthopedic trauma patients, and it suggests a potential inverse relationship with BMD in patients with vitamin D levels >30 ng/mL. The absence of osteoporosis in our population raises questions about the influence of vitamin D on BMD in this young trauma patient demographic. Future research should explore the impact of vitamin D replacement on fracture union and investigate the interaction between vitamin D levels and bone health in the younger orthopedic trauma population.
这项横断面研究的目的是调查年轻骨科创伤患者维生素D缺乏症的患病率及其对通过腰椎计算机断层扫描成像测量的骨密度（BMD）的影响。
在一级创伤中心进行的这项前瞻性横断面分析纳入了100例年龄在18至50岁之间的非脆性骨折患者。从计算机断层扫描中记录维生素D水平和腰椎的亨氏单位。排除标准包括脆性骨折、腰椎手术史或腰椎骨/转移性病变。评估维生素D水平与骨密度之间的相关性；维生素D缺乏定义为低于30 ng/mL。
在参与者中，75%维生素D缺乏，平均维生素D水平为25.0 ng/mL。根据亨氏单位，没有患者患有骨质疏松症；然而，5%的患者处于骨质减少范围内。在维生素D水平正常的患者中，维生素D水平与通过亨氏单位测量的骨密度之间存在负相关（P=0.025）。在这个非缺乏人群中，腰椎亨氏单位测量值越高，维生素D水平越低。
本研究突出了年轻骨科创伤患者中维生素D缺乏的高患病率，并表明在维生素D水平>30 ng/mL的患者中，维生素D与骨密度之间可能存在负相关。我们的人群中没有骨质疏松症，这引发了关于维生素D对这个年轻创伤患者群体骨密度影响的疑问。未来的研究应探讨维生素D替代对骨折愈合的影响，并研究年轻骨科创伤人群中维生素D水平与骨骼健康之间的相互作用。
