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原发性关节化脓性关节炎内科治疗与外科治疗结果的比较:一项单中心回顾性研究

Comparison of the results of medical approach and surgical approach of septic arthritis in native joints: a single-center retrospective study.

作者信息

Lu Qiyuan, Yang Xiaoqiang, Chen Mengmeng, Mao Zhiqiang, Ling Houfu

机构信息

Department of Orthopaedics, Yuyao Hospital of Traditional Chinese Medicine, Ningbo, Zhengjiang Province, 310000, China.

Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510006, China.

出版信息

BMC Musculoskelet Disord. 2024 Dec 30;25(1):1092. doi: 10.1186/s12891-024-08147-w.

Abstract

BACKGROUND

The consequences of septic arthritis of natural joints may be devastating. The purpose of this study was to evaluate the functional results of medical approach and surgical approach for septic arthritis of native joints, and to explore whether the number of drainage tubes after arthroscopic surgery will affect the knee function of patients.

METHODS

A single-center retrospective study was conducted on patients diagnosed with septic arthritis from January 2018 to January 2023. According to the improvement of clinical symptoms and daily activity ability of the joints, functional results of patients were divided into Complete recovery, Basic recovery, Minor recovery and No recovery. The main results are the joint function after medical and surgical approaches. The secondary outcome was knee function with different number of drainage tubes after arthroscopic surgery. Multivariate logistic regression analysis was used to determine the risk factors related to joint function. In addition, the types of bacteria were analyzed to explore whether they were related to the initial surgical failure rate.

RESULTS

Among the 77 patients with septic arthritis, 27 patients were treated with medical approach, and 50 patients were treated with surgical approach (knee arthroscopy + synovectomy). There was no significant difference in the results of joint function at discharge and 6 months after discharge. There was no significant difference in the number of drainage tubes after knee arthroscopy on the recovery of knee joint function. There were no risk factors independently associated with joint function outcomes in this study. In the cases of initial surgical failure, the treatment failure rate was 13.0% in the multidrug-sensitive bacteria group, 100% in the methicillin-resistant Staphylococcus aureus group, and 58.3% in the other multidrug-resistant bacteria group (P = 0.001).

CONCLUSIONS

The results of this study indicate that medical methods may be as effective as surgical methods for functional recovery in patients with septic arthritis. The number of drainage tubes after knee arthroscopy had no significant effect on the recovery of knee joint function. Maybe the type of bacteria (gram negative or more aggressive ones) can play a role in the choice of treatment strategy. Further prospective studies with better methodology are needed.

摘要

背景

天然关节的化脓性关节炎后果可能是毁灭性的。本研究的目的是评估内科治疗和手术治疗对天然关节化脓性关节炎的功能结果,并探讨关节镜手术后引流管数量是否会影响患者的膝关节功能。

方法

对2018年1月至2023年1月诊断为化脓性关节炎的患者进行单中心回顾性研究。根据关节临床症状和日常活动能力的改善情况,将患者的功能结果分为完全恢复、基本恢复、轻度恢复和未恢复。主要结果是内科和手术治疗后的关节功能。次要结果是关节镜手术后不同引流管数量的膝关节功能。采用多因素逻辑回归分析确定与关节功能相关的危险因素。此外,分析细菌类型以探讨它们是否与初始手术失败率有关。

结果

77例化脓性关节炎患者中,27例采用内科治疗,50例采用手术治疗(膝关节镜检查+滑膜切除术)。出院时和出院后6个月的关节功能结果无显著差异。膝关节镜检查后引流管数量对膝关节功能恢复无显著差异。本研究中没有独立于关节功能结果的危险因素。在初始手术失败的病例中,多重耐药菌组的治疗失败率为13.0%,耐甲氧西林金黄色葡萄球菌组为100%,其他多重耐药菌组为58.3%(P=0.001)。

结论

本研究结果表明,内科治疗方法在化脓性关节炎患者的功能恢复方面可能与手术方法一样有效。膝关节镜检查后引流管数量对膝关节功能恢复无显著影响。也许细菌类型(革兰氏阴性或更具侵袭性的细菌)在治疗策略的选择中可以发挥作用。需要进一步开展方法更好的前瞻性研究。

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本文引用的文献

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Native Joint Septic Arthritis.原发性关节化脓性关节炎
Antibiotics (Basel). 2024 Jun 27;13(7):596. doi: 10.3390/antibiotics13070596.

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