Savage D D, Rigsbee L C, McNamara J O
J Neurosci. 1985 Feb;5(2):408-13. doi: 10.1523/JNEUROSCI.05-02-00408.1985.
This report examines the effect of transection of the entorhinal hippocampal projection on amygdaloid kindling. We found that: bilateral knife cuts of entorhinal cortex but not of dorsal neocortex antagonize the development of amygdaloid kindling; and bilateral knife cuts of entorhinal cortex eliminate the seizure-induced decrease in number of muscarinic receptors of dentate granule cells. We suggest the following interpretations of these data: the hippocampal formation circuitry facilitates the development of amygdaloid kindling; and the decline of muscarinic receptors after kindled seizures is due to excessive activation of granule cells by axons from entorhinal cortex, a noncholinergic afferent.
本报告研究了内嗅海马投射切断对杏仁核点燃的影响。我们发现：双侧切断内嗅皮质而非背侧新皮质可拮抗杏仁核点燃的发展；双侧切断内嗅皮质可消除癫痫发作诱导的齿状颗粒细胞毒蕈碱受体数量减少。我们对这些数据提出以下解释：海马结构回路促进了杏仁核点燃的发展；点燃性癫痫发作后毒蕈碱受体的减少是由于来自内嗅皮质（一种非胆碱能传入神经）的轴突对颗粒细胞的过度激活所致。
