Fang Jincheng, Rao Xinrui, Wang Changjian, Wang Yangchenxi, Wu Chuangyan, Zhou Rui
Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science, Wuhan, China.
Front Pharmacol. 2024 Dec 16;15:1471476. doi: 10.3389/fphar.2024.1471476. eCollection 2024.
Non-small cell lung cancer (NSCLC) constitutes a significant proportion of lung cancer cases, and despite advancements in treatment modalities, radiotherapy resistance remains a substantial hurdle in effective cancer management. Exosomes, which are small vesicles secreted by cells, have emerged as pivotal players in intercellular communication and influence various biological processes, including cancer progression and the response to therapy. This review discusses the intricate role of exosomes in the modulation of NSCLC radiosensitivity. The paper focuses on NSCLC and highlights how tumor-derived exosomes contribute to radioresistance by enhancing DNA repair, modulating immune responses, and altering the tumor microenvironment. We further explore the potential of mesenchymal stem cell-derived exosomes to overcome radiotherapy resistance and their potential as biomarkers for predicting therapeutic outcomes. Understanding the mechanisms by which exosomes affect radiotherapy can provide new avenues for enhancing treatment efficacy and improving the survival rates of patients with NSCLC.
非小细胞肺癌（NSCLC）在肺癌病例中占相当大的比例，尽管治疗方式有所进步，但放疗抵抗仍然是有效癌症管理中的一个重大障碍。外泌体是细胞分泌的小囊泡，已成为细胞间通讯的关键参与者，并影响包括癌症进展和对治疗的反应在内的各种生物学过程。本综述讨论了外泌体在调节NSCLC放射敏感性中的复杂作用。本文重点关注NSCLC，并强调肿瘤来源的外泌体如何通过增强DNA修复、调节免疫反应和改变肿瘤微环境来导致放射抵抗。我们进一步探讨了间充质干细胞来源的外泌体克服放疗抵抗的潜力及其作为预测治疗结果生物标志物的潜力。了解外泌体影响放疗的机制可为提高治疗效果和改善NSCLC患者生存率提供新途径。
