两种含有[2(5H)-呋喃亚甲基]乙酸酯部分的格拉西醚和9,10-二氢普拉科尔酮G：来自加勒比海海洋海绵的新型聚酮化合物
Two Gracilioethers Containing a [2(5H)-Furanylidene]ethanoate Moiety and 9,10-Dihydroplakortone G: New Polyketides from the Caribbean Marine Sponge .
作者信息
Amador Luis A, Rodríguez Abimael D, Carmona-Sarabia Lesly, Colón-Lorenzo Emilee E, Serrano Adelfa E
机构信息
Molecular Sciences Research Center, University of Puerto Rico, 1390 Ponce de León Avenue, San Juan 00926, Puerto Rico.
Department of Microbiology and Medical Zoology, University of Puerto Rico School of Medicine, San Juan 00921, Puerto Rico.
出版信息
Appl Sci (Basel). 2024 Jan;14(1). doi: 10.3390/app14010281. Epub 2023 Dec 28.
Gracilioether M () and 11,12-dihydrogracilioether M (), two polyketides with a [2(5H)-furanylidene]ethanoate moiety, along with known plakortone G () and its new naturally occurring derivative 9,10-dihydroplakortone G (), were isolated from the Caribbean marine sponge . The structures and absolute configuration of , , and were characterized by analysis of HRESIMS and NMR spectroscopic data, chemical derivatization, and side-by-side comparisons with published NMR data of related analogs. Compounds and and a mixture of and were evaluated for cytotoxicity against MCF-7 human breast cancer cells. In addition, the in vitro antiplasmodial activity against of these compounds was scrutinized using a drug luminescence assay.
从加勒比海海绵中分离出了Gracilioether M（）和11,12 - 二氢Gracilioether M（），这两种聚酮化合物带有[2(5H)-呋喃亚甲基]乙酸酯部分，以及已知的软海绵素G（）及其新的天然存在的衍生物9,10 - 二氢软海绵素G（）。通过高分辨电喷雾电离质谱（HRESIMS）和核磁共振（NMR）光谱数据分析、化学衍生化以及与相关类似物已发表的NMR数据进行并排比较，对、和的结构及绝对构型进行了表征。评估了化合物和以及和的混合物对MCF - 7人乳腺癌细胞的细胞毒性。此外，使用药物发光测定法仔细研究了这些化合物对的体外抗疟原虫活性。
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