Hussain Amjad, Bourguet-Kondracki Marie-Lise, Majeed Maryam, Ibrahim Muhammad, Imran Muhammad, Yang Xian-Wen, Ahmed Ishtiaq, Altaf Ataf Ali, Khalil Anees Ahmed, Rauf Abdur, Wilairatana Polrat, Hemeg Hassan A, Ullah Riaz, Green Ivan R, Ali Iftikhar, Shah Syed Tasadaque A, Hussain Hidayat
Department of Chemistry University of Okara, Okara, Pakistan; Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
Biomed Pharmacother. 2023 Mar;159:114165. doi: 10.1016/j.biopha.2022.114165. Epub 2023 Jan 10.
Breast cancer, one of the most significant tumors among all cancer cells, still has deficiencies for effective treatment. Moreover, substitute treatments employing natural products as bioactive metabolites has been seriously considered. The source of bioactive metabolites are not only the most numerous but also represent the richest source. A unique source is from the oceans or marine species which demonstrated intriguing chemical and biological diversity which represents an astonishing reserve for discovering novel anticancer drugs. Notably, marine sponges produce the largest amount of diverse bioactive peptides, alkaloids, terpenoids, polyketides along with many secondary metabolites whose potential is mostly therapeutic. In this review, our main focus is on the marine derived secondary metabolites which demonstrated cytotoxic effects towards numerous breast cancer cells and have been isolated from the marine sources such as marine sponges, cyanobacteria, fungi, algae, tunicates, actinomycetes, ascidians, and other sources of marine organisms.
乳腺癌是所有癌细胞中最重要的肿瘤之一，但在有效治疗方面仍存在不足。此外，使用天然产物作为生物活性代谢物的替代疗法已得到认真考虑。生物活性代谢物的来源不仅数量最多，而且是最丰富的来源。一个独特的来源是海洋或海洋物种，它们展示了有趣的化学和生物多样性，这是发现新型抗癌药物的惊人储备。值得注意的是，海洋海绵产生了大量多样的生物活性肽、生物碱、萜类化合物、聚酮化合物以及许多次生代谢物，其潜力大多具有治疗作用。在这篇综述中，我们主要关注海洋来源的次生代谢物，这些次生代谢物对众多乳腺癌细胞具有细胞毒性作用，并且已从海洋来源如海洋海绵、蓝细菌、真菌、藻类、被囊动物、放线菌、海鞘和其他海洋生物来源中分离出来。
