Shen Yao, Qiu Ailin, Huang Xin, Wen Xiaosha, Shehzadi Sundar, He Yan, Hu Qian, Zhang Jian, Luo Dixian, Yang Shenghui
Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Front Immunol. 2024 Dec 16;15:1462174. doi: 10.3389/fimmu.2024.1462174. eCollection 2024.
Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases. Here, we review recent research progress on AKR1B10 in digestive system tumors such as hepatocellular carcinoma, gastric carcinoma, colorectal carcinoma, pancreatic carcinoma, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, and nasopharyngeal carcinoma, over the last 5 years. We also discuss the current trends and future research directions for AKR1B10 in both oncological and non-oncological diseases to provide a scientific reference for further exploration of this gene.
醛糖酮还原酶家族1成员B10（AKR1B10）是AKR1B亚家族的一员。它主要存在于细胞质中，在胃和肠道中典型表达。鉴于其在其他组织中表达低或无表达，AKR1B10是各种消化系统疾病潜在的诊断和治疗生物标志物。在此，我们综述了过去5年中AKR1B10在消化系统肿瘤如肝细胞癌、胃癌、结直肠癌、胰腺癌、口腔鳞状细胞癌、喉鳞状细胞癌、胆管癌和鼻咽癌等方面的最新研究进展。我们还讨论了AKR1B10在肿瘤性和非肿瘤性疾病中的当前趋势和未来研究方向，以为进一步探索该基因提供科学参考。
