Zhi Hui, Fu Hui, Zhang Yunxin, Fan Ni, Zhao Chengcheng, Li Yunfei, Sun Yujiao, Li Yingpeng
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Immunol. 2024 Dec 16;15:1510628. doi: 10.3389/fimmu.2024.1510628. eCollection 2024.
The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cytokines to enhance immune defenses against tumors and pathogens. However, dysregulated activation of the STING pathway is implicated in the pathogenesis of multiple diseases, including autoinflammation, viral infections, and cancer. Traditional Chinese Medicines (TCMs), which have a long history of use, have been associated with positive effects in disease prevention and treatment. TCM formulations (e.g., Lingguizhugan Decoction, Yi-Shen-Xie-Zhuo formula) and active compounds (e.g., Glabridin, Ginsenoside Rd) can modulate the cGAS-STING signaling pathway, thereby influencing the progression of inflammatory, infectious, or oncological diseases. This review explores the mechanisms by which TCMs interact with the cGAS-STING pathway to regulate immunity, focusing on their roles in infectious diseases, malignancies, and autoimmune disorders.
环鸟苷酸-腺苷酸合成酶-干扰素基因刺激蛋白（cGAS-STING）信号通路是固有免疫反应的关键组成部分，在多种疾病中发挥着重要作用。作为该通路的核心元件，STING可对内源性和外源性DNA刺激作出反应，触发干扰素和促炎细胞因子的产生，以增强针对肿瘤和病原体的免疫防御。然而，STING通路的异常激活与多种疾病的发病机制有关，包括自身炎症、病毒感染和癌症。有着悠久使用历史的中药已被证明在疾病预防和治疗中具有积极作用。中药配方（如苓桂术甘汤、益肾泄浊方）和活性成分（如光甘草定、人参皂苷Rd）可调节cGAS-STING信号通路，从而影响炎症性、感染性或肿瘤性疾病的进展。本综述探讨了中药与cGAS-STING通路相互作用以调节免疫的机制，重点关注它们在传染病、恶性肿瘤和自身免疫性疾病中的作用。
