Zhao Qianqian, Jin Meihua, Zhao Qiang, Wang Zhimei, Zhao Chun, Xue Xiaocong, Qiao Xikai, Qu Peng, Han Donghe, Tao Ran
Department of Anatomy, Medical College, Dalian University, Dalian, Liaoning, China.
Department of Immunology, Medical College, Dalian University, Dalian, Liaoning, China.
Front Pharmacol. 2025 Apr 16;16:1560567. doi: 10.3389/fphar.2025.1560567. eCollection 2025.
Renal fibrosis represents the terminal pathological manifestation of most chronic kidney diseases, driving progressive loss of renal function. Natural products have emerged as promising therapeutic agents for preventing and ameliorating renal fibrosis due to their multi-target efficacy and favorable safety profiles. In this review, we conducted a comprehensive literature search on PubMed using the keywords "natural product" and "renal fibrosis" from 2004 to 2025, identifying 704 relevant articles. We systematically categorize and discuss the biological effects of key natural products and formulations with antifibrotic potential, focusing on five major classes: glycosides, flavonoids, phenolic compounds, anthraquinones, and terpenoids. Representative compounds from each category are highlighted for their mechanisms of action, including modulation of oxidative stress, inflammation, autophagy, and fibrosis signaling pathways. This review aims to provide a theoretical foundation for the development of natural product-based therapies to combat renal fibrosis, offering insights into their therapeutic potential and future research directions.
肾纤维化是大多数慢性肾脏病的终末期病理表现，导致肾功能进行性丧失。天然产物因其多靶点功效和良好的安全性，已成为预防和改善肾纤维化的有前景的治疗药物。在本综述中，我们于2004年至2025年期间在PubMed上使用关键词“天然产物”和“肾纤维化”进行了全面的文献检索，共识别出704篇相关文章。我们系统地分类并讨论了具有抗纤维化潜力的关键天然产物和制剂的生物学效应，重点关注五大类：糖苷、黄酮类、酚类化合物、蒽醌类和萜类。突出了每一类中的代表性化合物的作用机制，包括对氧化应激、炎症、自噬和纤维化信号通路的调节。本综述旨在为开发基于天然产物的抗肾纤维化疗法提供理论基础，深入了解其治疗潜力和未来研究方向。
