Kapp J P, Clower B R, Azar F M, Yabuno N, Smith R R
J Neurosurg. 1985 Apr;62(4):570-5. doi: 10.3171/jns.1985.62.4.0570.
Subarachnoid hemorrhage (SAH) was produced in cats by transorbital rupture of the right middle cerebral artery (MCA). In untreated cats, widespread proliferative angiopathy occurred in both MCA's by 16 days after SAH. In cats that received systemic heparin, the pathological events following SAH were clearly reduced in the ruptured artery, and were not present in the contralateral left MCA. Platelets are known to adhere to the subintimal surface of cerebral arteries after SAH. The authors suggest that platelet-derived growth factor released from the intimal platelet carpet following SAH may be the stimulus for the development of proliferative angiopathy, and that this platelet factor is inhibited by heparin.
通过经眶穿刺使猫的右侧大脑中动脉（MCA）破裂，从而造成蛛网膜下腔出血（SAH）。在未经治疗的猫中，SAH后16天时双侧MCA均出现广泛的增殖性血管病。在接受全身肝素治疗的猫中，SAH后破裂动脉中的病理事件明显减少，对侧左侧MCA未出现病理事件。已知SAH后血小板会黏附于脑动脉的内膜下表面。作者认为，SAH后从内膜血小板层释放的血小板衍生生长因子可能是增殖性血管病发展的刺激因素，并且这种血小板因子会被肝素抑制。
