Nguyen Quyen Thi To, Nguyen Phuc Van, Ho Phuong Hoang, Le Khiem Tan, Le Thanh Anh, Nguyen Truc Thi Thuy
Diagnostic Imaging Center, Tam Anh General Hospital, Ho Chi Minh City, Vietnam.
Front Oncol. 2024 Dec 16;14:1387813. doi: 10.3389/fonc.2024.1387813. eCollection 2024.
Basal ganglia germinomas are uncommon neoplasms. Basal ganglia germinomas exhibit high sensitivity to both radiation therapy and chemotherapy. In contrast, surgery is the standard treatment for most primary brain tumors (such as gliomas, which are the most common tumors in the pediatric basal ganglia region). A 21-year-old male patient was admitted to our hospital because of unexplained right-sided hemiparesis for two years. Biomarkers indicating germ cell tumors are typically negative. On the initial MRI, the abnormalities were nonspecific, causing no suspicion of a tumor. Therefore, the patient did not receive an earlier diagnosis or treatment. His brain MRI revealed a mass with more apparent features one year later. Based on the imaging characteristics of conventional and advanced MR images, the preoperative radiological diagnosis was highly likely to reveal germinomas. The patient then underwent a biopsy and received appropriate treatment. Despite treatment, his symptoms only partially improved. Accurate preoperative diagnosis is crucial for ensuring that patients receive appropriate treatment and to help avoid more invasive surgery. Additionally, early identification of germinomas is also important for improving long-term patient outcomes and preventing tumor spread due to delayed diagnosis. Therefore, we aim to review and report this case to assist radiologists in recognizing and becoming familiar with the early imaging signs of basal ganglia germinoma.
基底节生殖细胞瘤是罕见的肿瘤。基底节生殖细胞瘤对放射治疗和化疗均表现出高度敏感性。相比之下，手术是大多数原发性脑肿瘤（如胶质瘤，是小儿基底节区最常见的肿瘤）的标准治疗方法。一名21岁男性患者因不明原因的右侧偏瘫两年入住我院。提示生殖细胞肿瘤的生物标志物通常为阴性。初次MRI检查时，异常表现不具有特异性，未引起对肿瘤的怀疑。因此，该患者未得到早期诊断和治疗。一年后，他的脑部MRI显示出具有更明显特征的肿块。根据常规和先进MR图像的影像学特征，术前放射学诊断极有可能提示生殖细胞瘤。该患者随后接受了活检并接受了适当治疗。尽管进行了治疗，他的症状仅部分改善。准确的术前诊断对于确保患者接受适当治疗并帮助避免更具侵入性的手术至关重要。此外，早期识别生殖细胞瘤对于改善患者长期预后以及防止因诊断延迟导致肿瘤扩散也很重要。因此，我们旨在回顾并报告该病例，以帮助放射科医生识别并熟悉基底节生殖细胞瘤的早期影像学征象。
