Cheng Jinjun, Wang Yannan, Gong Shunyou, Wistinghausen Birte, Jacobs Shana, Schore Reuven J, Toner Keri
Department of Pathology and Laboratory Medicine.
Centers for Cancer and Blood Disorders and Cancer and Immunology Research, Children's National Hospital.
J Pediatr Hematol Oncol. 2025 Jan 1;47(1):e58-e61. doi: 10.1097/MPH.0000000000002967. Epub 2024 Dec 31.
Children with T-ALL/LBL require prompt diagnosis and treatment. Flow cytometric analysis of T-lineage and immaturity markers usually leads to a straightforward diagnosis. However, rare cases of T-ALL expressing bright CD45 and lacking expression of immature markers can be a diagnostic conundrum and difficult to differentiate from mature T-cell lymphomas lacking surface CD3 expression or aberrantly expressing immature markers, which affects treatment decisions and prognosis. Here, we summarize the clinical, pathologic, and genetic features of 3 pediatric T-ALL cases with an entirely mature immunophenotype.
患有T-ALL/LBL的儿童需要及时诊断和治疗。对T系和不成熟标志物进行流式细胞术分析通常可得出明确诊断。然而，罕见的T-ALL病例表现为明亮的CD45表达且缺乏不成熟标志物的表达，这可能成为诊断难题，并且难以与缺乏表面CD3表达或异常表达不成熟标志物的成熟T细胞淋巴瘤相鉴别，而这会影响治疗决策和预后。在此，我们总结了3例具有完全成熟免疫表型的儿童T-ALL病例的临床、病理和遗传学特征。
