Dorfman David M
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Cancers (Basel). 2025 Mar 26;17(7):1111. doi: 10.3390/cancers17071111.
Lymphoblastic leukemia/lymphoma, a neoplasm of precursor B or T lineage lymphoid cells, usually involves the bone marrow and peripheral blood, and may involve nodal and/or extranodal sites. The diagnosis is based on morphologic assessment, immunophenotypic analysis, usually by flow cytometry, and genetic analysis, including cytogenetics and FISH analysis, as well as molecular diagnostic analysis. This review will focus on the flow cytometric immunophenotypic findings in B- and T-lymphoblastic leukemia/lymphoma, which include expressions of early B or T cell markers, low-level expressions of CD45, as well as expressions of terminal deoxynucleotidyl transferase (TdT), and, in many cases, stem/progenitor cell marker CD34.
淋巴细胞白血病/淋巴瘤是一种前体B或T系淋巴样细胞的肿瘤，通常累及骨髓和外周血，也可能累及淋巴结和/或结外部位。诊断基于形态学评估、免疫表型分析（通常通过流式细胞术）、遗传分析（包括细胞遗传学和荧光原位杂交分析）以及分子诊断分析。本综述将聚焦于B淋巴细胞白血病/淋巴瘤和T淋巴细胞白血病/淋巴瘤的流式细胞术免疫表型结果，这些结果包括早期B或T细胞标志物的表达、CD45的低水平表达、末端脱氧核苷酸转移酶（TdT）的表达，并且在许多情况下，还包括干/祖细胞标志物CD34的表达。
