Tian Qu, Greig Erin E, Davatzikos Christos, Landman Bennett A, Resnick Susan M, Ferrucci Luigi
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Radiology Department, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nat Commun. 2024 Dec 30;15(1):10786. doi: 10.1038/s41467-024-55009-z.
Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer's disease and neurodegeneration. Here, we examine its associations with up to over a decade-long changes in brain atrophy and microstructure. Higher in vivo skeletal muscle oxidative capacity via MR spectroscopy (post-exercise recovery rate, k) is associated with less ventricular enlargement and brain aging progression, and less atrophy in specific regions, notably primary sensorimotor cortex, temporal white and gray matter, thalamus, occipital areas, cingulate cortex, and cerebellum white matter. Higher k is also associated with less microstructural integrity decline in white matter around cingulate, including superior longitudinal fasciculus, corpus callosum, and cingulum. Higher in vivo muscle oxidative capacity is associated with preserved brain structure up to over a decade, particularly in areas important for cognition, motor function, and sensorimotor integration.
肌肉线粒体氧化能力受损与未来的认知障碍以及阿尔茨海默病和神经退行性变的PET和血液生物标志物水平升高有关。在此，我们研究了它与长达十多年的脑萎缩和微观结构变化之间的关联。通过磁共振波谱法测量的较高的体内骨骼肌氧化能力（运动后恢复率，k）与较少的脑室扩大和脑老化进展相关，并且在特定区域的萎缩较少，特别是初级感觉运动皮层、颞叶白质和灰质、丘脑、枕叶区域、扣带回皮层和小脑白质。较高的k还与扣带回周围白质（包括上纵束、胼胝体和扣带）的微观结构完整性下降较少有关。较高的体内肌肉氧化能力与长达十多年的脑结构保留有关，特别是在对认知、运动功能和感觉运动整合重要的区域。
