Escala Andrés
Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago, Chile.
Sci Rep. 2024 Dec 30;14(1):31707. doi: 10.1038/s41598-024-82671-6.
Multiple physiological traits correlates with lifespan, being unclear both the causal connection among them and with the process of ageing. In this paper, we show that six traits (such as metabolic rate, mass, heart rate, etc) acting at the system level, are all related to lifespan thru the existence of an approximately constant number of respiration cycles in a lifespan ([Formula: see text]), therefore, we find that those relationships are not independently related to ageing. In addition, we study if the approximately constant [Formula: see text] is possibly linked with the end-of-lifespan somatic mutation burden, another number recently found to be approximately constant (Cagan, Nature 604:517-524, 2022). We find that the dataset of mammals studied is consistent with a direct proportionality between the somatic mutation rate and the respiration frequency, being a tentative link between both invariant numbers.
多种生理特征与寿命相关，它们之间的因果关系以及与衰老过程的关系都尚不清楚。在本文中，我们表明在系统水平上起作用的六个特征（如代谢率、体重、心率等），通过寿命中存在大致恒定数量的呼吸周期（[公式：见正文]）都与寿命相关，因此，我们发现这些关系并非独立于衰老相关。此外，我们研究了大致恒定的[公式：见正文]是否可能与寿命末期体细胞突变负担相关，体细胞突变负担是最近发现的另一个大致恒定的数值（卡根，《自然》604:517 - 524，2022）。我们发现所研究的哺乳动物数据集与体细胞突变率和呼吸频率之间的直接比例关系一致，这是这两个不变数值之间的一种初步联系。
