Xie Xinlong, Wu Fanfan, Zhuang Zhiruo, Xu Aijun
School of Health Economics and Management, Nanjing University of Chinese Medicine, Nanjing, China.
Jiangsu Research Center for Major Health Risk Management and TCM Control Policy, Nanjing University of Chinese Medicine, Nanjing, China.
Sci Rep. 2024 Dec 30;14(1):31832. doi: 10.1038/s41598-024-83130-y.
This study investigates the bidirectional relationship between social isolation and cognitive function among older adults in China, utilizing data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). The baseline survey, which commenced in 2008, tracked 1,662 participants over four waves of data collection spanning a decade. We employed Cross-Lagged Panel Models (CLPM) and Random Intercept Cross-Lagged Panel Models (RI-CLPM) to analyze these relationships at both the between-person and within-person levels. CLPM results indicated significant cross-lagged effects between social isolation (β = - 0.119, p < 0.001; β = - 0.162, p < 0.001) and cognitive function (β = - 0.073, p < 0.001; β = - 0.091, p < 0.001) at the between-person level over the last three waves. Specifically, higher prior levels of social isolation were associated with a significant decline in subsequent cognitive function, and vice versa. Furthermore, RI-CLPM results showed that, after controlling for random intercepts and covariates, only social isolation had a significant negative impact on cognitive function across all waves (β = - 0.051, p < 0.05; β = - 0.047, p < 0.05; β = - 0.028, p < 0.05). Overall, this study demonstrates that, when considering both between-person and within-person effects, social isolation exerts a stronger lag effect on cognitive function among older adults in China. This suggests that, over a specific timeframe, reducing social isolation is crucial for promoting healthy aging in this population.
本研究利用中国老年健康长寿纵向调查(CLHLS)的数据,调查了中国老年人社会隔离与认知功能之间的双向关系。始于2008年的基线调查,在跨越十年的四轮数据收集过程中追踪了1662名参与者。我们采用交叉滞后面板模型(CLPM)和随机截距交叉滞后面板模型(RI-CLPM),在个体间和个体内层面分析这些关系。CLPM结果表明,在过去三轮调查中,个体间层面的社会隔离(β = -0.119,p < 0.001;β = -0.162,p < 0.001)与认知功能(β = -0.073,p < 0.001;β = -0.091,p < 0.001)之间存在显著的交叉滞后效应。具体而言,较高的先前社会隔离水平与随后认知功能的显著下降相关,反之亦然。此外,RI-CLPM结果显示,在控制随机截距和协变量后,仅社会隔离在所有轮次中对认知功能有显著负面影响(β = -0.051,p < 0.05;β = -0.047,p < 0.05;β = -0.028,p < 0.05)。总体而言,本研究表明,在考虑个体间和个体内效应时,社会隔离对中国老年人的认知功能具有更强的滞后效应。这表明,在特定时间段内,减少社会隔离对于促进该人群的健康老龄化至关重要。