Schnizler Stephan, Naumann Michael, Vieth Michael
Institute of Pathology, Klinikum Bayreuth, 95445, Bayreuth, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.
Histochem Cell Biol. 2024 Dec 31;163(1):22. doi: 10.1007/s00418-024-02345-2.
A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological and diseased human gastric tissues to gain deeper insights into its involvement in gastric pathologies. We analyzed paraffin-embedded gastric tissue samples from 326 patients. A20 expression was assessed using immunohistochemistry (IHC) with results categorized according to the Remmele and Stegner immunoreactive score (IRS). The study compared A20 expression across a spectrum of gastric pathologies, including Helicobacter pylori (HP) gastritis, autoimmune gastritis (A-gastritis), reactive gastropathy (C-gastritis), Ex-HP-gastritis, adenomas, and adenocarcinomas, with nonpathological gastric mucosa serving as a baseline. Our findings demonstrate a significant increase in A20 expression in HP-gastritis (p = 0.019), A-gastritis (p = 0.001), adenomas (p < 0.001), and adenocarcinomas (p < 0.001). Conversely, no significant differences in A20 expression were observed in C-gastritis or Ex-HP-gastritis cases.
A20是一种泛素编辑酶，在调节细胞信号传导和免疫反应中起关键作用。A20表达失调与多种病理状况相关，包括炎症性疾病和恶性肿瘤，在实体瘤中其表达水平常与不同的预后相关。本研究旨在探讨A20在非病理和患病人类胃组织中的表达及细胞定位，以更深入了解其在胃部病理中的作用。我们分析了326例患者的石蜡包埋胃组织样本。使用免疫组织化学（IHC）评估A20表达，并根据Remmele和Stegner免疫反应评分（IRS）对结果进行分类。该研究将包括幽门螺杆菌（HP）胃炎、自身免疫性胃炎（A胃炎）、反应性胃病（C胃炎）、根除HP后胃炎、腺瘤和腺癌在内的一系列胃部病理中的A20表达与作为基线的非病理胃黏膜进行了比较。我们的研究结果表明，HP胃炎（p = 0.019）、A胃炎（p = 0.001）、腺瘤（p < 0.001）和腺癌（p < 0.001）中A20表达显著增加。相反，在C胃炎或根除HP后胃炎病例中未观察到A20表达的显著差异。
