Wang Zhi, Zhang Haokun, Shao Zilong
Department of Emergency Medicine, Taikang Tongji (Wuhan) Hospital, 322 North Sixin Street, Hanyang, Wuhan, 430050, Hubei, People's Republic of China.
School of Public Health and Health Management, Gannan Medical University, Ganzhou, 341000, People's Republic of China.
Sci Rep. 2024 Dec 30;14(1):32132. doi: 10.1038/s41598-024-83971-7.
Metabolic syndrome (MetS) presents substantial health risks, and the supplementation of probiotics and prebiotics is regarded as a promising management approach. This study aims to explore the relationship between dietary intake of live microbes and non-dietary prebiotic/probiotic intake and MetS among US adults.
Data from the National Health and Nutrition Examination Survey 1999-2016 was used in this study. MetS is defined according to the criteria set by the National Cholesterol Education Program-Adult Treatment Panel III-2005. Dietary intake information and probiotic/prebiotic intake data were collected through self-reported questionnaires. Multiple logistic models were applied to explore the relationships between dietary live microbes, and probiotic or prebiotic intake with MetS.
A significantly lower prevalence of MetS was observed in individuals with a high intake of dietary live microbes compared to those with a low intake (OR: 0.79, 95% CI: 0.69-0.91). This association was particularly strong among participants with higher economic status and advanced educational attainment (interaction P < 0.05). Similarly, individuals with non-dietary probiotics intake displayed a similar trend (OR: 0.70, 95% CI: 0.54-0.92). Conversely, there was no significant association found between non-dietary prebiotic intake and MetS.
Dietary live microbes intake and non-dietary probiotic intake were negatively associated with the prevalence of MetS and its components. The study offers novel evidence supporting the effective management of MetS.
代谢综合征（MetS）带来了重大的健康风险，补充益生菌和益生元被视为一种有前景的管理方法。本研究旨在探讨美国成年人饮食中活微生物的摄入量、非饮食性益生元/益生菌的摄入量与代谢综合征之间的关系。
本研究使用了1999 - 2016年美国国家健康与营养检查调查的数据。代谢综合征根据美国国家胆固醇教育计划成人治疗小组第三次报告（2005年）设定的标准来定义。饮食摄入信息和益生菌/益生元摄入数据通过自我报告问卷收集。应用多重逻辑模型来探讨饮食中活微生物、益生菌或益生元摄入量与代谢综合征之间的关系。
与低摄入量的个体相比，高摄入量的饮食活微生物个体中代谢综合征的患病率显著较低（比值比：0.79，95%置信区间：0.69 - 0.91）。这种关联在经济状况较好和教育程度较高的参与者中尤为显著（交互作用P < 0.05）。同样，摄入非饮食性益生菌的个体也呈现出类似趋势（比值比：0.70，95%置信区间：0.54 - 0.92）。相反，未发现非饮食性益生元摄入量与代谢综合征之间存在显著关联。
饮食中活微生物的摄入量和非饮食性益生菌的摄入量与代谢综合征及其组成部分的患病率呈负相关。该研究提供了新的证据支持对代谢综合征的有效管理。
