Zhao Rui, Lian Wenqin, Xu Qiong
Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Tianhe District, Guangzhou, 510623, Guangdong, China.
Department of Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Tianhe District, Guangzhou, 510623, Guangdong, China.
Discov Oncol. 2024 Dec 31;15(1):849. doi: 10.1007/s12672-024-01675-w.
Ovarian cancer continues to be a major cause of morbidity and mortality in women, with immune regulation playing a critical role in its progression and treatment response. This review explores the interplay between sex hormones, particularly estrogen and progesterone, and immune regulation in ovarian cancer. We delve into the mechanisms by which these hormones influence immune cell function, modulate immune checkpoints, and alter the tumor microenvironment. Key pathways involving estrogen and progesterone receptors are examined, highlighting their impact on tumor growth and immune evasion. The review also discusses the therapeutic implications of these interactions, including the potential for combining hormone-based therapies with immune checkpoint inhibitors. Personalized medicine approaches, leveraging biomarkers for predicting treatment response, are considered essential for optimizing patient outcomes. Finally, we address current research gaps and future directions, emphasizing the need for advanced research technologies and novel therapeutic strategies to improve the treatment of ovarian cancer through a better understanding of hormone-immune interactions.
卵巢癌仍然是女性发病和死亡的主要原因，免疫调节在其进展和治疗反应中起着关键作用。本综述探讨了性激素，特别是雌激素和孕激素，与卵巢癌免疫调节之间的相互作用。我们深入研究了这些激素影响免疫细胞功能、调节免疫检查点以及改变肿瘤微环境的机制。研究了涉及雌激素和孕激素受体的关键途径，突出了它们对肿瘤生长和免疫逃逸的影响。该综述还讨论了这些相互作用的治疗意义，包括将基于激素的疗法与免疫检查点抑制剂联合使用的可能性。利用生物标志物预测治疗反应的个性化医疗方法，被认为是优化患者治疗效果的关键。最后，我们阐述了当前的研究空白和未来方向，强调需要先进的研究技术和新颖的治疗策略，以通过更好地理解激素 - 免疫相互作用来改善卵巢癌的治疗。
