Alsaadi Taoufik, Al Madani AbuBakar, Alhatou Mohammed, Nada Mona, Albilali Abdulrazaq, Al-Qassabi Ahmed, Mohamed Hegab, Mohamed Haytham, El Masry Rowan, Saifuddin Ghaidaa Ahmed, AlRukn Suhail Abdullah
Chair of the Department of Neurology, American Center for Psychiatry and Neurology, Abu Dhabi, United Arab Emirates.
Department of Neurology, Rashid Hospital, Dubai, United Arab Emirates.
Pain Ther. 2025 Feb;14(1):145-183. doi: 10.1007/s40122-024-00686-3. Epub 2024 Dec 30.
Migraine is a debilitating neurological disorder characterized by recurrent throbbing, moderate-to-severe headaches that disrupt daily chores, leisure, and social activities of patients, impacting their overall quality of life (QoL). Despite the high disease burden, there is a scarcity of data on migraines within the Middle East (ME) region. Thus, a systematic literature review (SLR) was conducted to examine epidemiological data, treatment patterns, QoL, and unmet needs regarding migraines in the ME region.
Electronic searches were carried out using the MEDLINE® and Embase® databases via the OvidSP® platform for articles published prior to April 2024. The inclusion and exclusion criteria for the selection of studies were based on the Patients, Intervention, Comparator, Outcomes, and Study design framework, which identified 42 studies.
The prevalence of migraines reported from the region ranged between 2.6 and 32%, and the average age of patients with migraines reported in these studies ranged from 27 to 37.5 years. The data indicated a gender disparity in migraine prevalence, with women exhibiting a 2- to 2.5-fold higher prevalence. Common comorbidities reported were depression, anxiety, and irritable bowel disease. Migraines significantly impact patients' physical and emotional well-being, leading to disabilities and loss of productivity. The most common triggers of migraines were sleep disorders, dietary habits, and stress. The current treatment landscape for acute migraines encompasses anti-inflammatory agents, analgesics, triptans, ditans, calcitonin-gene-related peptides, and antiemetics. However, migraines in the region are often underestimated, underreported, and undertreated. Several unmet needs persist in the region, including delayed referral along with delayed diagnosis, misdiagnosis, poor treatment adherence, limited accessibility to treatments, and a lack of awareness among health care providers and patients.
The SLR highlights knowledge gaps in clinical aspects and the treatment of migraines and enables clinicians to make informed decisions to ensure optimal patient outcomes in diverse clinical settings.
偏头痛是一种使人衰弱的神经系统疾病，其特征为反复发作的搏动性、中度至重度头痛，会扰乱患者的日常琐事、休闲和社交活动，影响他们的整体生活质量（QoL）。尽管疾病负担沉重，但中东（ME）地区关于偏头痛的数据却很匮乏。因此，开展了一项系统文献综述（SLR），以研究中东地区偏头痛的流行病学数据、治疗模式、生活质量和未满足的需求。
通过OvidSP®平台使用MEDLINE®和Embase®数据库对2024年4月之前发表的文章进行电子检索。研究选择的纳入和排除标准基于患者、干预措施、对照、结局和研究设计框架，共确定了42项研究。
该地区报告的偏头痛患病率在2.6%至32%之间，这些研究中报告的偏头痛患者的平均年龄在27至37.5岁之间。数据表明偏头痛患病率存在性别差异，女性患病率高出2至2.5倍。报告的常见合并症有抑郁症、焦虑症和肠易激综合征。偏头痛对患者的身心健康有显著影响，导致残疾和生产力丧失。偏头痛最常见的诱因是睡眠障碍、饮食习惯和压力。目前急性偏头痛的治疗方法包括抗炎药、镇痛药、曲坦类药物、双氢麦角胺类药物、降钙素基因相关肽和止吐药。然而，该地区的偏头痛常常被低估、报告不足且治疗不充分。该地区仍存在一些未满足的需求，包括转诊延迟以及诊断延迟、误诊、治疗依从性差、治疗可及性有限，以及医疗保健提供者和患者缺乏认识。
该系统文献综述突出了偏头痛临床方面和治疗中的知识空白，并使临床医生能够做出明智的决策，以确保在不同临床环境中实现最佳患者结局。
